Huperzine A, a novel promising acetylcholinesterase inhibitor

doi:10.1097/00001756-199612200-00020

	Huperzine A, a novel promising acetylcholinesterase inhibitor
	Cheng, DH; Ren, H; Tang, XC
刊名	NEUROREPORT
	1996-12-20
卷号	8 期号:1 页码:97-101
关键词	Alzheimer's disease cholinesterase inhibitor E2020 huperzine A memory radial maze scopolamine tacrine
ISSN号	0959-4965
DOI	10.1097/00001756-199612200-00020
文献子类	Article
英文摘要	THE effects of huperzine A on memory impairments induced by scopolamine were evaluted using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg(-1)) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg(-1), p.o.), E2020 (0.5-1.0 mg kg(-1), p.o.) and tacrine (1.0-2.0 mg kg(-1), p.o) could reverse these scopolamine-induced memory deficits. The ratios of huperzine A, E2020 and tacrine for butyrylcholinesterase:acetylcholinesterase determined by a colourimetric method were 884.57, 489.05, and 0.80, respectively. The results demonstrated that huperzine A was the most selective acetylcholinterase inhibitor, and improved the working memory deficit induced by scopolamine significantly better than did E2020 or tacrine, suggesting it may be a promising agent for clinical therapy of cognitive impairment in patients with Alzheimer's Disease.
WOS关键词	ALZHEIMERS-DISEASE ; SENILE DEMENTIA ; MEMORY ; ABNORMALITIES ; SYSTEM ; RAT
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:A1996WX33900021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274943]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室
作者单位	CHINESE ACAD SCI, SHANGHAI INST MAT MED, STATE KEY LAB DRUG RES, SHANGHAI 200031, PEOPLES R CHINA
推荐引用方式 GB/T 7714	Cheng, DH,Ren, H,Tang, XC. Huperzine A, a novel promising acetylcholinesterase inhibitor[J]. NEUROREPORT,1996,8(1):97-101.
APA	Cheng, DH,Ren, H,&Tang, XC.(1996).Huperzine A, a novel promising acetylcholinesterase inhibitor.NEUROREPORT,8(1),97-101.
MLA	Cheng, DH,et al."Huperzine A, a novel promising acetylcholinesterase inhibitor".NEUROREPORT 8.1(1996):97-101.