Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat

doi:10.1016/S0014-2999(01)01030-5

	Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat
	Wang, R; Zhang, HY; Tang, XC
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2001-06-15
卷号	421 期号:3 页码:149-156
关键词	(-)-huperzine A beta-amyloid protein Alzheimer's disease amnesia model apoptosis apoptosis-related protein
ISSN号	0014-2999
DOI	10.1016/S0014-2999(01)01030-5
文献子类	Article
英文摘要	Huperzine A, a promising therapeutic agent for Alzheimer's disease, was examined for its potential to antagonize the deleterious neurochemical, structural, and cognitive effects of infusing beta -amyloid protein-(1-40) into the cerebral ventricles of rats. Daily intraperitoneal administration of huperzine A for 12 consecutive days produced significant reversals of the beta -amyloid-induced deficit in learning a water maze task. This treatment also reduced the loss of choline acetyltransferase activity in cerebral cortex, and the neuronal degeneration induced by beta -amyloid protein-(1-40). In addition, huperzine A partly reversed the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bar and P53 proteins and reduced the apoptosis that normally followed beta -amyloid injection. The present findings confirm that huperzine A can alleviate the cognitive dysfunction induced by intracerebroventricular infusion of beta -amyloid protein-(1-40) in rats. The beneficial effects are not confined to the cholinergic system, but also include favorable changes in the expression of apoptosis-related proteins and in the extent of apoptosis in widespread regions of the brain. (C) 2001 Elsevier Science B.V. All rights reserved.
WOS关键词	APOPTOTIC CELL-DEATH ; ALZHEIMERS-DISEASE ; SENILE DEMENTIA ; PEPTIDE ; ACETYLCHOLINESTERASE ; NEUROTOXICITY ; EXPRESSION ; PRECURSOR ; INFUSION ; PLAQUES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000169552300002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274480]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Tang, XC
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Wang, R,Zhang, HY,Tang, XC. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2001,421(3):149-156.
APA	Wang, R,Zhang, HY,&Tang, XC.(2001).Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.EUROPEAN JOURNAL OF PHARMACOLOGY,421(3),149-156.
MLA	Wang, R,et al."Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat".EUROPEAN JOURNAL OF PHARMACOLOGY 421.3(2001):149-156.