Protein phosphatase 2A: Its structure, function and activity regulation

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	Protein phosphatase 2A: Its structure, function and activity regulation
	Liu, WJ; Shen, Y; Ding, J
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2003-02
卷号	35 期号:2 页码:105-112
关键词	protein phosphatase 2A(PP2A) holoenzyme complex core dimer enzyme
ISSN号	0582-9879
文献子类	Review
英文摘要	Protein phosphatase 2A ( PP2A) is a major kind of serine/threonine protein phosphatase in eukaryotic cells. PP2A has many subunits and isozymes encoded by different genes to form many different PP2A holo-enzymes. PP2A play important roles in regulation of cell cycle, signal transduction, cell differentiation, and transformation. Its activity is related to several diseases, including neurodegenerative diseases and cancer. The regulation of PP2A activity is accomplished by its subunits' expression, cellular localization, phosphorylation and methylation. The second messenger, ceramide, also plays an important role in the regulation of PP2A activity, as well as a plenty of low molecular mass inhibitors of PP2A and other protein phosphatases.
WOS关键词	CATALYTIC SUBUNIT ; BCL2 PHOSPHORYLATION ; SIGNAL-TRANSDUCTION ; DNA-REPLICATION ; C-ALPHA ; BINDING ; FAMILY ; CANCER ; PP2A ; DEPHOSPHORYLATION
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	中文
出版者	SHANGHAI INST BIOCHEMISTRY, ACADEMIA SINICA
WOS记录号	WOS:000181245500001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274265]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Div Anti Tumor Pharmacol, State Key Lab Drug Res,Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Liu, WJ,Shen, Y,Ding, J. Protein phosphatase 2A: Its structure, function and activity regulation[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(2):105-112.
APA	Liu, WJ,Shen, Y,&Ding, J.(2003).Protein phosphatase 2A: Its structure, function and activity regulation.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(2),105-112.
MLA	Liu, WJ,et al."Protein phosphatase 2A: Its structure, function and activity regulation".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.2(2003):105-112.