Feitai attenuates bleomycin-induced pulmonary fibrosis in rats

doi:10.1248/bpb.27.634

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物安全性评价中心

	Feitai attenuates bleomycin-induced pulmonary fibrosis in rats
	Gong, LK; Li, XH; Wang, H ; Zhang, L ; Cai, Y ; Qi, XM; Liu, LL ; Liu, YZ; Wu, XF ; Chen, FP
刊名	BIOLOGICAL & PHARMACEUTICAL BULLETIN
	2004-05
卷号	27 期号:5 页码:634-640
关键词	Feitai pulmonary fibrosis bleomycin rat
ISSN号	0918-6158
DOI	10.1248/bpb.27.634
文献子类	Article
英文摘要	Pulmonary fibrosis is a common consequence of numerous pulmonary diseases. The current therapeutic approaches for this condition are unsatisfactory. Feitai, a composite formula consisting of several herbs, is used in China as a folk remedy for treating patients with pulmonary tuberculosis. In this study, we extensively investigate the effects and mechanisms of Feitai on bleomycin (BLM)-induced pulmonary fibrosis in rats. One hundred and twenty male Sprague-Dawley rats were randomly divided into four groups, referred to as the saline-water, saline-Feitai, BLM-water, and BLM-Feitai groups. Following a single instillation of BLM (5 mg/kg) or saline, rats were orally administered Feitai at a dose of 3 g/kg body weight or sterilized distilled water once daily. Rats were killed at 7, 14, or 28 d post-BLM. Inflammatory cell count, protein concentration, and lactate dehydrogenase activity in bronchoalveolar lavage fluid were measured, and myeloperoxidase activity and lipid peroxide content in lung homogenates were analyzed. Treatment with Feitai inhibited lung fibrotic progression induced by BLM, as indicated by the decrease in lung hydroproline content and lung fibrosis score at 28 d post-BLM. This was accompanied by significant amelioration of BLM-induced body weight loss, lung edema, and inflammatory response during the development of lung injury in the acute phase. The results strongly indicate the beneficial effects of Feitai in protecting against BLM-induced pulmonary fibrosis. Furthermore, the inflammatory response and lipid peroxidation were inhibited by Feitai, suggesting that the effect of this formula on BLM-induced lung injury and fibrosis is associated with antiinflammatory and antioxidant properties.
WOS关键词	INDUCED LUNG FIBROSIS ; N-ACETYLCYSTEINE ; GROWTH-FACTOR ; MICE ; INJURY ; PATHOGENESIS ; SUPEROXIDE ; SURFACTANT ; TOXICITY ; DAMAGE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	PHARMACEUTICAL SOC JAPAN
WOS记录号	WOS:000221161200008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274082]
专题	药物安全性评价中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ren, J
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China 2.Shanghai Pulm Hosp, Shanghai 200043, Peoples R China
推荐引用方式 GB/T 7714	Gong, LK,Li, XH,Wang, H,et al. Feitai attenuates bleomycin-induced pulmonary fibrosis in rats[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2004,27(5):634-640.
APA	Gong, LK.,Li, XH.,Wang, H.,Zhang, L.,Cai, Y.,...&Ren, J.(2004).Feitai attenuates bleomycin-induced pulmonary fibrosis in rats.BIOLOGICAL & PHARMACEUTICAL BULLETIN,27(5),634-640.
MLA	Gong, LK,et al."Feitai attenuates bleomycin-induced pulmonary fibrosis in rats".BIOLOGICAL & PHARMACEUTICAL BULLETIN 27.5(2004):634-640.