Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis

doi:10.1016/j.ejphar.2004.04.053

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	Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis
	Tong, YG ; Zhang, XW ; Zhao, WM; Zhang, YX ; Lang, JY ; Shi, YH; Tan, WF ; Li, MH ; Zhang, YW ; Tong, LJ
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2004-06-28
卷号	494 期号:2-3 页码:101-109
关键词	Shiraiachrome A angiogenesis inhibitor arthritis receptor tyrosine kinase
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2004.04.053
文献子类	Article
英文摘要	The Chinese folk medicine Shiraia bambusicola has long been utilized in the treatment of rheumatoid arthritis, a disease in which angiogenesis plays an important role. We report here the isolation of the compound Shiraiachrome A from S. bambusicola and the demonstration of its anti-angiogenic properties. We found that Shiraiachrome A significantly inhibited the proliferation, migration, and tube formation of human microvascular endothelial cells (HMEC) in a dose-dependent manner, with average IC50 values of 2.1 +/- 0.36, 1.97 +/- 0.44, and 1.65 +/- 0.59 muM, respectively. In addition, Shiraiachrome A inhibited the formation of new microvessels in a rat aorta culture model as well as in the chick embryo chorioallantoic membrane (CAM) assay. Investigation of the mechanism of action of Shiraiachrome A demonstrated that this compound suppressed the autophosphorylation of four receptor tyrosine kinases (RTKs), with IC50 values ranging from 2.2 to 4.3 muM. These results suggest that Shiraiachrome A inhibits angiogenesis by blocking growth factor-stimulated autophosphorylation of RTKs. These findings also indicate that Shiraiachrome A may be a potent therapeutic agent for angiogenesis-related diseases such as cancer, rheumatoid arthritis, and diabetic retinopathy. (C) 2004 Elsevier B.V. All rights reserved.
WOS关键词	ENDOTHELIAL GROWTH-FACTOR ; COLLAGEN-INDUCED ARTHRITIS ; RECEPTOR TYROSINE KINASES ; TUBE FORMATION ; FACTOR VEGF ; INHIBITION ; SUPPRESSION ; EXPRESSION ; MECHANISMS ; AGM-1470
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000222398600003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274056]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ding, J
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Div Anti Tumor Pharmacol,State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Phytochem, Shanghai 201203, Peoples R China 3.St Louis Hosp Paris, INSERM, U553, Shanghai 200031, Peoples R China 4.Ruijin Hosp, Pols Sci Sino Francais Rech Sci Vivant, SIMM, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Tong, YG,Zhang, XW,Zhao, WM,et al. Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2004,494(2-3):101-109.
APA	Tong, YG.,Zhang, XW.,Zhao, WM.,Zhang, YX.,Lang, JY.,...&Ding, J.(2004).Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis.EUROPEAN JOURNAL OF PHARMACOLOGY,494(2-3),101-109.
MLA	Tong, YG,et al."Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis".EUROPEAN JOURNAL OF PHARMACOLOGY 494.2-3(2004):101-109.