Targeting sphingosine-1-phosphate signaling for cancer therapy

doi:10.1007/s11427-017-9046-6

	Targeting sphingosine-1-phosphate signaling for cancer therapy
	Xie, Zuoquan1 ; Liu, Hong2 ; Geng, Meiyu1
刊名	SCIENCE CHINA-LIFE SCIENCES
	2017-06
卷号	60 期号:6 页码:585-600
关键词	sphingosine-1-phosphate sphingosine ceramide cancer inflammation immunity
ISSN号	1674-7305
DOI	10.1007/s11427-017-9046-6
文献子类	Review
英文摘要	Sphingosine-1-phosphate (S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival, cell proliferation, cell migration, angiogenesis and many other cellular processes. S1P either activates S1P receptors (S1PR1-5) through "inside-out signaling" or acts directly on intracellular targets to regulate various cellular processes. In the past two decades, much progress has been made in exploring S1P signaling and its pathogenic roles in diseases as well as in developing modulators of S1P signaling, including S1P agonists, S1P antagonists and sphingosine kinase (SphK) inhibitors. Ceramide and S1P have been defined as reciprocal regulators of cell fate, and S1P signaling has been shown to be crucial for the pathogenesis of various diseases, including autoimmune diseases, inflammation and cancer; therefore, targeting S1P signaling may curtail the process of pathogenesis and serve as a potential therapeutic target for the treatment of these diseases. In this review, we describe recent advances in our understanding of S1P signaling in cancer development (particularly in inflammation-associated cancer) as well as in innate and adaptive immunity, and we also discuss modulators of S1P signaling in cancer treatment.
资助项目	National Natural Science Foundation of China[91229204] ; Major Project of the Chinese National Programs for Fundamental Research and Development[2015CB910304]
WOS关键词	SPHINGOSINE KINASE 1 ; PROTEIN-COUPLED RECEPTOR ; COLITIS-ASSOCIATED CANCER ; GROWTH-FACTOR RECEPTOR ; 2 INHIBITOR ABC294640 ; GENE-DEFICIENT MICE ; B-CELL LYMPHOMA ; CHRONIC INTESTINAL INFLAMMATION ; PERSISTENT STAT3 ACTIVATION ; HEART TRANSPLANTATION MODEL
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
CSCD记录号	CSCD:6041148
出版者	SCIENCE PRESS
WOS记录号	WOS:000404775400004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272633]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Liu, Hong; Geng, Meiyu
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Chem, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xie, Zuoquan,Liu, Hong,Geng, Meiyu. Targeting sphingosine-1-phosphate signaling for cancer therapy[J]. SCIENCE CHINA-LIFE SCIENCES,2017,60(6):585-600.
APA	Xie, Zuoquan,Liu, Hong,&Geng, Meiyu.(2017).Targeting sphingosine-1-phosphate signaling for cancer therapy.SCIENCE CHINA-LIFE SCIENCES,60(6),585-600.
MLA	Xie, Zuoquan,et al."Targeting sphingosine-1-phosphate signaling for cancer therapy".SCIENCE CHINA-LIFE SCIENCES 60.6(2017):585-600.