Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis

doi:10.1021/acs.orglett.7b02181

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	Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis
	Fan, Yao-Yue 2; Gan, Li-She 1; Liu, Hong-Chun2 ; Li, Heng 2; Xu, Cheng-Hui 2; Zuo, Jian-Ping2 ; Ding, Jian2 ; Yue, Jian-Min2
刊名	ORGANIC LETTERS
	2017-09-01
卷号	19 期号:17 页码:4580-4583
ISSN号	1523-7060
DOI	10.1021/acs.orglett.7b02181
文献子类	Article
英文摘要	Phainanolide A (1), a highly modified triterpenoid incorporating an unprecedented 6/9/6 heterotricyclic system and a highly oxygenated 5,5-spirocyclic ketal lactone, along with three new triterpenoids 2-4 were isolated from Phyllanthus hainanensis. Their structures were completely elucidated by a combination of diverse methods including 2D NMR, quantum chemical NMR and ECD calculations, and NMR data analogy with model compounds. Compounds 1-4 exhibited both remarkable cytotoxic and immunosuppressive activities.
资助项目	National Natural Science Foundation of the P. R China[21532007] ; National Natural Science Foundation of the P. R China[U1302222] ; "Personalized Medicines-Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020321]
WOS关键词	KARPLUS EQUATION ; HYDROGEN-BOND ; DICHAPETALINS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000409566400043
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272506]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Ding, Jian; Yue, Jian-Min
作者单位	1.Zhejiang Univ, Inst Modern Chinese Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Fan, Yao-Yue,Gan, Li-She,Liu, Hong-Chun,et al. Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis[J]. ORGANIC LETTERS,2017,19(17):4580-4583.
APA	Fan, Yao-Yue.,Gan, Li-She.,Liu, Hong-Chun.,Li, Heng.,Xu, Cheng-Hui.,...&Yue, Jian-Min.(2017).Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis.ORGANIC LETTERS,19(17),4580-4583.
MLA	Fan, Yao-Yue,et al."Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis".ORGANIC LETTERS 19.17(2017):4580-4583.