Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position

doi:10.1002/adsc.201700484

	*CpRh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position**
	Wang, Bao 1,2,3; Li, Chunpu 1,3; Liu, Hong1,2,3
刊名	ADVANCED SYNTHESIS & CATALYSIS
	2017-09-04
卷号	359 期号:17 页码:3029-3034
关键词	Quinoline N-Oxides C-H Methylation Rhodium
ISSN号	1615-4150
DOI	10.1002/adsc.201700484
文献子类	Article
英文摘要	Herein, we report a Cp*Rh(III)-catalyzed directed C-H methylation of quinoline N-oxides at the C-8 position using commercially available organotrifluoroborates as reagents. This method features perfect regioselectivity, relatively mild reaction conditions, and diverse functional group tolerance with good to excellent yields. Additionally, direct C-8 arylated quinoline N-oxides products could also be obtained under the same conditions. Preliminary mechanistic experiments were conducted and a possible mechanism was proposed.
资助项目	National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[81602975] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National S&T Major Projects[2014ZX09507002-001]
WOS关键词	CROSS-COUPLING REACTION ; BOND ACTIVATION ; BORONIC ACIDS ; MILD CONDITIONS ; FUNCTIONALIZATION ; ALKYLATION ; ALKYNES ; ARENES ; HETEROARENES ; DISCOVERY
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000408941200017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272488]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Liu, Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Bao,Li, Chunpu,Liu, Hong. Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position[J]. ADVANCED SYNTHESIS & CATALYSIS,2017,359(17):3029-3034.
APA	Wang, Bao,Li, Chunpu,&Liu, Hong.(2017).Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position.ADVANCED SYNTHESIS & CATALYSIS,359(17),3029-3034.
MLA	Wang, Bao,et al."Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position".ADVANCED SYNTHESIS & CATALYSIS 359.17(2017):3029-3034.