Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana

doi:10.1021/acs.jnatprod.7b00241

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	Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana
	Xiong, Juan 1; Wan, Jiang 1,2; Ding, Jie 2; Wang, Pei-Pei3 ; Ma, Guang-Lei 1; Li, Jia3 ; Hu, Jin-Feng 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2017-11
卷号	80 期号:11 页码:2874-2882
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.7b00241
文献子类	Article
英文摘要	Seven new naturally occurring barrigenol-like compounds, camellianols A-G (1-7), and 10 known triterpenoids were isolated from the twigs and leaves of the cultivated endangered ornamental plant Camellia crapnelliana. According to the ECD octant rule for saturated cyclohexanones, the absolute configurations of camellianols D (4) and E (5) were defined. The backbones of the remaining new isolates are assumed to have the same absolute configuration as compounds 4, 5, and harpullone (12). Compounds 2, 3, 9, 10, 13, and 16 exhibited inhibitory effects on the protein tyrosine phosphatase 1B (PTP1B) enzyme, with IC50 values less than 10 mu M.
资助项目	NSFC[81202420] ; NSFC[21472021]
WOS关键词	TYROSINE-PHOSPHATASE 1B ; SHED TRUNK BARKS ; CHEMICAL-CONSTITUENTS ; CHLORANTHUS-SESSILIFOLIUS ; PENTACYCLIC TRITERPENOIDS ; ABIES-BESHANZUENSIS ; PINUS-DABESHANENSIS ; HARPULLIA-PENDULA ; NATURAL-PRODUCTS ; DITERPENOIDS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000416500400002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272417]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心国家新药筛选中心
通讯作者	Ding, Jie; Hu, Jin-Feng
作者单位	1.Fudan Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 201203, Peoples R China; 2.Sichuan Univ Sci & Engn, Sch Chem Engn, Zigong 643000, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Juan,Wan, Jiang,Ding, Jie,et al. Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(11):2874-2882.
APA	Xiong, Juan.,Wan, Jiang.,Ding, Jie.,Wang, Pei-Pei.,Ma, Guang-Lei.,...&Hu, Jin-Feng.(2017).Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana.JOURNAL OF NATURAL PRODUCTS,80(11),2874-2882.
MLA	Xiong, Juan,et al."Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana".JOURNAL OF NATURAL PRODUCTS 80.11(2017):2874-2882.