C-21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes

doi:10.1016/j.fitote.2017.11.014

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	C-21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes
	Qin, Jun-Jun 2,3; Chen, Xi 1,4; Lin, Ze-Min 4; Xu, Yan-Sheng 4; Li, Yi-Ming 4; Zuo, Jian-Ping5 ; Zhao, Wei-Min2
刊名	FITOTERAPIA
	2018-01
卷号	124 页码:193-199
关键词	Cynanchum bungei C-21-steroidal glycosides Sesquiterpenes
ISSN号	0367-326X
DOI	10.1016/j.fitote.2017.11.014
文献子类	Article
英文摘要	Phytochemical investigation of the roots of Cynanchum bungei Decne (Asclepiadaceae) led to the elucidation of seven Cm-steroidal glycosides (1-7) including three new compounds (1-3), named cynabungosides A-C, one new eudesmane-type sesquiterpene (8), named cynabungone, and one new humulane-type sesquiterpene (9), named cynabungolide. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of 8 and 9 were defined unequivocally by ECD analysis and X-ray crystallography, respectively. A putative biosynthetic pathway of humulane-type sesquiterpenes 9 and 10 is proposed.
资助项目	National Natural Science Foundation[81273399]
WOS关键词	C-21 STEROIDAL GLYCOSIDES ; PREGNANE GLYCOSIDES ; PERIPLOCA-SEPIUM ; CONSTITUENTS ; AURICULATUM ; WILFORDII ; DECNE ; ASCLEPIADACEAE ; ACETOPHENONES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000423888000029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272336]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Zuo, Jian-Ping; Zhao, Wei-Min
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Shanghai Univ Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201210, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Qin, Jun-Jun,Chen, Xi,Lin, Ze-Min,et al. C-21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes[J]. FITOTERAPIA,2018,124:193-199.
APA	Qin, Jun-Jun.,Chen, Xi.,Lin, Ze-Min.,Xu, Yan-Sheng.,Li, Yi-Ming.,...&Zhao, Wei-Min.(2018).C-21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes.FITOTERAPIA,124,193-199.
MLA	Qin, Jun-Jun,et al."C-21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes".FITOTERAPIA 124(2018):193-199.