Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy
Hu, Haiyan2; Wang, Jing2; Wang, Hong1,3; Tang, Tao1,3; Li, Jie1,3; Wang, Zhiwan1,3; Sun, Kaoxiang2; Li, Yaping1,2,3; Zhang, Zhiwen1,3
刊名THERANOSTICS
2018
卷号8期号:13页码:3597-3610
关键词lymph metastasis cell-penetrating peptide nanovehicle micelles deep penetration
ISSN号1838-7640
DOI10.7150/thno.25608
文献子类Article
英文摘要Lymph metastasis is a vital pathway of cancer cell dissemination, and insidious lymph node metastasis increases the risk of distant cancer metastasis. Current therapies for lymph metastasis are largely restricted by limited targeting and penetration capacity. Herein, we report that an r9 cell-penetrating peptide-based cabazitaxel nanovehicle (r9-CN) displays prominent lymph metastasis targeting and deep penetration ability after intravenous injection for effective anti-metastasis therapy. Methods: The r9-CN and CN nanovehicles were prepared by thin film dispersion, using DSPE-PEG2000 as the nano-carrier material and cabazitaxel as the model drug to fabricate r9-modified nano-micelles by self-assembly. The morphology, size, and stability in physiological solutions of r9-CN and CN were characterized. The targeting, biodistribution, deep penetration, and therapeutic efficacy of r9-CN and CN were systematically explored in vitro and in vivo. Results: The r9-CN nanovehicle consists of homogeneous particles with a mean diameter of 13 nm and zeta potential of +0.75 mV. Compared with the nanovehicle lacking the r9 peptide (CN), r9-CN exhibits long retention and deep penetration in the tumor mass, and considerably enhances accumulation and flexible permeation in metastatic lymph nodes, thereby notably suppressing primary tumor growth, lymph node metastasis, and distant lung metastasis. Conclusion: The cumulative findings reveal that r9-CN offers a promising delivery platform, enabling efficient lymph metastasis targeting and deep penetration for effective anti-metastasis therapy.
资助项目National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[00000000]
WOS关键词GUIDED PHOTOTHERMAL THERAPY ; INHIBIT CANCER METASTASIS ; NODE METASTASIS ; BREAST-CANCER ; DRUG-DELIVERY ; TUMOR-TISSUE ; LUNG-CANCER ; NEOADJUVANT CHEMOTHERAPY ; EXTRACELLULAR-MATRIX ; POLYMERIC MICELLES
WOS研究方向Research & Experimental Medicine
语种英语
出版者IVYSPRING INT PUBL
WOS记录号WOS:000435485300012
内容类型期刊论文
源URL[http://119.78.100.183/handle/2S10ELR8/272310]  
专题药物制剂研究中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Sun, Kaoxiang; Li, Yaping; Zhang, Zhiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ,Collaborat Innovat Ctr Adv Drug Deliv, Yantai 264005, Shandong, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Hu, Haiyan,Wang, Jing,Wang, Hong,et al. Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy[J]. THERANOSTICS,2018,8(13):3597-3610.
APA Hu, Haiyan.,Wang, Jing.,Wang, Hong.,Tang, Tao.,Li, Jie.,...&Zhang, Zhiwen.(2018).Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy.THERANOSTICS,8(13),3597-3610.
MLA Hu, Haiyan,et al."Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy".THERANOSTICS 8.13(2018):3597-3610.
个性服务
查看访问统计
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。


©版权所有 ©2017 CSpace - Powered by CSpace