Serine/threonine protein kinase Akt and Akt targeting  anticancer drug development

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Serine/threonine protein kinase Akt and Akt targeting anticancer drug development
	LIU Lunhua; LOU Liguang
刊名	Chinese Pharmacological Bulletin
	2006
卷号	22 期号:1 页码:1-4
关键词	Akt protein Akt phosphatidylinositol 3-kinase targeted drug signal transduction anticancer drug
ISSN号	1001-1978
其他题名	丝／苏氨酸蛋白激酶Akt及其靶向药物研究进展
文献子类	Review
英文摘要	Dyregulation of serine/threonine protein kinase Akt/PKB activity is a prominent feature of many human cancers. A large number of studies have demonstrated that Akt plays a key role in mediating cell growth and proliferation, promoting cell migration and invasion, stimulating neoangiogenesis, and protecting from pro-apoptotic stimuli. In view of the highly pleiotropic biologic effects of Akt signaling in multiple aspects of tumor pathophysiology, development of clinically applicable drugs specifically targeting Akt has been the subject of intense research. Up to now, a number of Akt specific inhibitors such as API-2, Akt- I-1, Akt-I-2 and DCIEL have been developed and investigated in pre-clinical studies. These compounds have been shown to potently inhibit growth of tumors with aberrantly expressed or activated Akt, therefore, are likely to be developed as promising targeted anticancer drugs.
资助项目	国家自然科学基金资助项目[00000000]
WOS研究方向	Oncology ; Public, Environmental & Occupational Health (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2308794
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268209]
专题	药理学第一研究室中科院受体结构与功能重点实验室药物安全性评价中心
通讯作者	LOU Liguang
作者单位	Shanghai Institute of Materia Medica, Shanghai lntitute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	LIU Lunhua,LOU Liguang. Serine/threonine protein kinase Akt and Akt targeting anticancer drug development[J]. Chinese Pharmacological Bulletin,2006,22(1):1-4.
APA	LIU Lunhua,&LOU Liguang.(2006).Serine/threonine protein kinase Akt and Akt targeting anticancer drug development.Chinese Pharmacological Bulletin,22(1),1-4.
MLA	LIU Lunhua,et al."Serine/threonine protein kinase Akt and Akt targeting anticancer drug development".Chinese Pharmacological Bulletin 22.1(2006):1-4.