Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor

doi:10.7536/PC150437

	Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor
	Zeng Feng 1,2; Pan Zhenzhen 1,2; Zhang Meng 1; Huang Yongzhuo1 ; Cui Yanna 1; Xu Qin 2
刊名	PROGRESS IN CHEMISTRY
	2015-10
卷号	27 期号:10 页码:1356-1373
关键词	ordered mesoporous structure silica nanoparticles synthesis and modification tumor diagnosis and therapy
ISSN号	1005-281X
DOI	10.7536/PC150437
文献子类	Review
英文摘要	Ordered mesoporous silica nanoparticles (MSNs) have drawn a great deal of attention in the biomedical fields because of their specific structures and unique physical chemistry properties. Combined with various functional materials or molecules, such as magnetic nanoparticles, fluorescent probes, antineoplastic drugs and targeting ligands, ordered mesoporous silica nanoparticles can be developed into the multifunctional nanomedicines in the application of diagnosis and therapy of tumor. The recent progress on synthetic methods, surface modification and application of MSNs are reviewed. First of all, the methods of synthesis in different pH medium and template removal are summarized in detail along with a brief introduction on their merits and drawbacks. Secondly, surface modification methods are described, including surface stabilization and surface functionalization. Thirdly, the application progress of targeted therapy and imaging diagnosis of MSNs loaded with imaging agents or chemotherapy drugs are also concluded. The final part outlines the challenges and perspectives.
资助项目	National Natural Science Foundation of China[81402885] ; Chinese Postdoctoral Science Foundation[2014M551475]
WOS关键词	TARGETED DRUG-DELIVERY ; IN-VIVO ; COLLOIDAL SUSPENSIONS ; MULTIDRUG-RESISTANCE ; ORGANIC TEMPLATES ; SPHERICAL MCM-48 ; POROUS MATERIALS ; CANCER-THERAPY ; PARTICLE-SIZE ; THIN-FILMS
WOS研究方向	Chemistry
语种	中文
CSCD记录号	CSCD:5590821
出版者	CHINESE ACAD SCIENCES
WOS记录号	WOS:000364260900003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276378]
专题	中国科学院上海药物研究所
通讯作者	Cui Yanna
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China; 2.Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zeng Feng,Pan Zhenzhen,Zhang Meng,et al. Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor[J]. PROGRESS IN CHEMISTRY,2015,27(10):1356-1373.
APA	Zeng Feng,Pan Zhenzhen,Zhang Meng,Huang Yongzhuo,Cui Yanna,&Xu Qin.(2015).Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor.PROGRESS IN CHEMISTRY,27(10),1356-1373.
MLA	Zeng Feng,et al."Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor".PROGRESS IN CHEMISTRY 27.10(2015):1356-1373.