Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats

	Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats
	Ma, TC; Zhu, XZ
刊名	ACTA PHARMACOLOGICA SINICA
	1997-03
卷号	18 期号:2 页码:121-123
关键词	interleukin-6 nitric oxide avoidance learning hippocampus nitroprusside
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the effect of intrahippocampal infusion of interleukin-6 (IL-6) on active avoidance in rats and the possible involvement of nitric oxide (NO). METHODS: Using a shuttle-box model, the effects of bilaterally intrahippocampal infusion of IL-6 3.2, 16, and 80 ng as well as sodium nitroprusside (SNP) 400 ng on active avoidance were studied on d 8 after administration. The levels of nitrite as an index of NO in the hippocampus were detected using a fluorometric assay 24 h after infusion of IL-6 3.2 or 80 ng. RESULTS: IL-6 16 and 80 ng impaired the acquisition performance of active avoidance by prolonging the latency of avoidance in training, but not the retention performance in testing. IG-6 80 ng and SNP 400 ng also resulted in a marked impairment in acquisition performances by decreasing the rate bf avoidance, but not in retention performances. IL-6 80 ng markedly elevated the nitrite levels from 10.6 +/- 0.7 in control rats to 13,6 +/- 2.0 (nmol/g wet wt) (P < 0.01). IL-6 3.2 ng had no effect on active avoidance nor on nitrite levels. CONCLUSION: Intrahippocampal infusion of IL-6 impaired learning acquisition of active avoidance in rats.
WOS关键词	HIPPOCAMPAL NITRIC-OXIDE ; MEMORY ; INHIBITION ; NO
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1997WM32200007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274918]
专题	中国科学院上海药物研究所
通讯作者	Ma, TC
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	Ma, TC,Zhu, XZ. Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats[J]. ACTA PHARMACOLOGICA SINICA,1997,18(2):121-123.
APA	Ma, TC,&Zhu, XZ.(1997).Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats.ACTA PHARMACOLOGICA SINICA,18(2),121-123.
MLA	Ma, TC,et al."Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats".ACTA PHARMACOLOGICA SINICA 18.2(1997):121-123.