Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis

doi:10.3748/wjg.v9.i3.534

	Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis
	Zhang, SC ; Wang, W ; Ren, WY ; He, BM ; Zhou, K ; Zhu, WN
刊名	WORLD JOURNAL OF GASTROENTEROLOGY
	2003-03
卷号	9 期号:3 页码:534-538
ISSN号	1007-9327
DOI	10.3748/wjg.v9.i3.534
文献子类	Article
英文摘要	AIM: To investigate the effects of cisapride on intestinal bacterial overgrowth (IBO), bacterial and endotoxin translocation, intestinal transit and permeability in cirrhotic rats. METHODS: All animals were assessed with variables including bacterial and endotoxin translocation, intestinal bacterial overgrowth, intestinal transit and permeability. Bacterial translocation (BT) was assessed by bacterial culture of MLN, liver and spleen, IBO by a jejunal bacterial count of the specific organism, intestinal permeability by determination of the 24-hour urinary Tc-99m-DTPA excretion and intestinal transit by measurement of the distribution of Cr-51 in the intestine. RESULTS: Bacterial translocation (BT) and IBO was found in 48 % and 80 % cirrhotic rats respectively and none in control rats. Urinary excretion of Tc-99m-DTPA in cirrhotic rats with BT (22.2 +/- 7.8) was greater than these without BT (10.5 +/- 2.9). Intestinal transit (geometric center ratio) was significantly delayed in cirrhotic rats (0.31 +/- 0.06) and further more delayed in cirrhotic rats with BT (0.24 +/- 0.06) than these without BT (0.38 +/- 0.11). Cirrhotic rats with IBO had significantly higher rates of intestinal bacterial and endotoxin translocation, slower intestinal transit time and higher intestinal permeability than those without IBO. It was also found that BT was closely associated with IBO and the injury of intestinal barrier. Compared with the placebo group, cisapride-treated rats had lower rates of bacterial/endotoxin translocation and IBO, which was closely associated with increased intestinal transit and improved intestinal permeability by cisapride. CONCLUSION: These results indicate that endotoxin and bacterial translocation in cirrhotic rats may be attributed to IBO and increased intestinal permeability. Cisapride that accelerates intestinal transit and improve intestinal permeability might be helpful in preventing intestinal bacterial and endotoxin translocation.
WOS关键词	SMALL-BOWEL MOTILITY ; LIVER-CIRRHOSIS ; PORTAL-HYPERTENSION ; RATS ; PERITONITIS ; OVERGROWTH ; ASCITES ; TRANSIT ; DECONTAMINATION ; PERMEABILITY
WOS研究方向	Gastroenterology & Hepatology
语种	英语
出版者	W J G PRESS
WOS记录号	WOS:000181745400032
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274260]
专题	中国科学院上海药物研究所
通讯作者	Zhang, SC
作者单位	1.Chinese Acad Sci, Inst Materia Med, Shanghai 200032, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Zhang, SC,Wang, W,Ren, WY,et al. Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(3):534-538.
APA	Zhang, SC,Wang, W,Ren, WY,He, BM,Zhou, K,&Zhu, WN.(2003).Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis.WORLD JOURNAL OF GASTROENTEROLOGY,9(3),534-538.
MLA	Zhang, SC,et al."Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis".WORLD JOURNAL OF GASTROENTEROLOGY 9.3(2003):534-538.