The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats

doi:10.1124/jpet.105.094821

	The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats
	Clozel, M ; Hess, P ; Qiu, CB ; Ding, SS ; Rey, M
刊名	JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
	2006-03
卷号	316 期号:3 页码:1115-1121
ISSN号	0022-3565
DOI	10.1124/jpet.105.094821
文献子类	Article
英文摘要	Urotensin-II ( U-II) is a cyclic peptide that acts through a specific G-protein-coupled receptor, UT receptor. Urotensin-II and UT receptors have been described in pancreas and kidney, but their function is not well understood. We studied the effects of chronic treatment of diabetic rats with the orally active selective U-II receptor antagonist palosuran. Streptozotocin treatment causes pancreatic beta-cell destruction and leads to the development of hyperglycemia, dyslipidemia, and renal dysfunction. Long-term treatment of streptozotocin-induced diabetic rats with palosuran improved survival, increased insulin, and slowed the increase in glycemia, glycosylated hemoglobin, and serum lipids. Furthermore, palosuran increased renal blood flow and delayed the development of proteinuria and renal damage. The U-II system is unique in that it plays a role both in insulin secretion and in the renal complications of diabetes. Urotensin receptor antagonism might be a new therapeutic approach for the treatment of diabetes.
WOS关键词	INCREASED EXPRESSION ; HUMAN TISSUES ; COHO SALMON ; MELLITUS ; VASOCONSTRICTOR ; HYPERTENSION ; NEPHROPATHY ; LOCALIZATION ; SOMATOSTATIN ; CLEARANCE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
WOS记录号	WOS:000235476000018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273661]
专题	中国科学院上海药物研究所
通讯作者	Clozel, M
作者单位	1.Actelion Pharmaceut Ltd, CH-4123 Allschwil, Switzerland 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Clozel, M,Hess, P,Qiu, CB,et al. The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,2006,316(3):1115-1121.
APA	Clozel, M,Hess, P,Qiu, CB,Ding, SS,&Rey, M.(2006).The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,316(3),1115-1121.
MLA	Clozel, M,et al."The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats".JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 316.3(2006):1115-1121.