Microbial transformation of cephalomannine by Luteibacter sp.

doi:10.1021/np0701531

	Microbial transformation of cephalomannine by Luteibacter sp.
	Li, Jianhua; Dai, Jungui; Chen, Xiaoguang; Zhu, Ping
刊名	JOURNAL OF NATURAL PRODUCTS
	2007-12
卷号	70 期号:12 页码:1846-1849
ISSN号	0163-3864
DOI	10.1021/np0701531
文献子类	Article
英文摘要	Luteibacter sp., a new bacterium isolated from the soil around a Taxus cuspidata Sieb. et Zucc plant, was studied for its capability to metabolize cephalomannine (1). After preparative fermentation, eight metabolites were obtained and characterized as baccatin III (2), baccatin V (3), 10-deacetylbaccatin III (4), 10-deacetyl-10-oxobaccatin V (5), 7-epicephalomannine (6), 10-deacetylcephalomannine (7), 10-deacetyl-7-epicephalomannine (8), and 3'-N-debenzoyl-3'-N-(2-methylbutyryl)-7-epitaxol (9). Among these metabolites, 9 is a new compound. Epimerization of the 7 beta-OH group and hydrolysis of the C-13 side-chain were the two major reactions in this bioprocess. However, the biotransformation of 7 beta-D-Xylosyl- 10-deacetyltaxol (10) with the same strain yielded a C-13 side-chain eliminated product without epimerization at C-7 (11). Metabolites 5-9 and 11, together with 1 and paclitaxel, were evaluated for their inhibitory activities against five human cancer cell lines (HCT-8, Be-7402, BGC-823, A549, and A2780). All these compounds showed less potent activities than paclitaxel, which is currently used in clinical chemotherapy.
WOS关键词	TAXUS-YUNNANENSIS ; TAXANES ; DITERPENOIDS ; WALLICHIANA ; TAXOL
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000252046700002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273108]
专题	中国科学院上海药物研究所
通讯作者	Dai, Jungui
作者单位	Chinese Acad Sci, Inst Mat Med, Dept Biosynth Nat Prod, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Li, Jianhua,Dai, Jungui,Chen, Xiaoguang,et al. Microbial transformation of cephalomannine by Luteibacter sp.[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(12):1846-1849.
APA	Li, Jianhua,Dai, Jungui,Chen, Xiaoguang,&Zhu, Ping.(2007).Microbial transformation of cephalomannine by Luteibacter sp..JOURNAL OF NATURAL PRODUCTS,70(12),1846-1849.
MLA	Li, Jianhua,et al."Microbial transformation of cephalomannine by Luteibacter sp.".JOURNAL OF NATURAL PRODUCTS 70.12(2007):1846-1849.