Alkaloids from lotus leaf and related bioactivities

	Alkaloids from lotus leaf and related bioactivities
	Yuan Pulong 1; Chen Liang 1; Liu Xiaoyu 2; Yu Bangwei 3; Haung Qi 3; Chen Kaixian1 ; Li Yiming 1; Jia Qi 1
刊名	Chinese Traditional Patent Medicine
	2014
卷号	36 期号:11 页码:2330-2333
关键词	lotus leaf(Nelumbo nucifera) alkaloids 2-hydroxy-l-methoxyaporphine antibacterial lipid-lowering hypoglycemic
ISSN号	1001-1528
其他题名	荷叶生物碱分离及相关活性研究
文献子类	Article
英文摘要	AIM To isolate alkaloids from lotus leaf and study their antimicrobial,hypoglycemic and lipid-lowering activities of the isolated alkaloids. METHODS Column chromatography and spectra analysis were used to separate and identify alkaloids from lotus leaf,broth microdilution method was employed to the antibacterial activity of the compounds on ten kinds of common pathogenic bacteria and fungi,while 4-nitrophenyl acetate and 4nitrophenyl-D-glucopyranoside as substrates were used to measure the inhibitory activity of pancreatic lipase and alpha- glucosidase enzyme,respectively. RESULTS Six alkaloids were isolated from lotus leaf and identified as nuciferine,2-hydroxy-l-methoxyaporphine,liriodenine,lysicamine,nornuciferine and armepavine. Bioassay showed that liriodenine had the same MIC values of 32 mug / mL against Escherichia coli,Bacillus subtilis and Staphylococcus aureus while that for armepavine against Trichophyton rubrum and Microsporum gypseum were 16 mug / mL as well. Under the 300 mumol / L inhibitory level,liriodenine and 2-hydroxy-l-methoxyaporphine on alpha -glucosidase enzyme were 40. 29% 3. 06% and 27. 62% 2. 21%,respectively. CONCLUSIONS 2-hydroxy-l-methoxyaporphine has certain inhibitory activity of alpha -glucosidase enzyme.
资助项目	国家自然科学基金[00000000]
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5283252
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269309]
专题	中国科学院上海药物研究所
作者单位	1.Department of Phytochemistry,College of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; 2.Department of Biochemistry,College of Pharmacy,Second Military Medical University, Shanghai 200433, China.; 3.The Third Department of Pharmacology,Shanghai Institute of Materia Medica, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Yuan Pulong,Chen Liang,Liu Xiaoyu,et al. Alkaloids from lotus leaf and related bioactivities[J]. Chinese Traditional Patent Medicine,2014,36(11):2330-2333.
APA	Yuan Pulong.,Chen Liang.,Liu Xiaoyu.,Yu Bangwei.,Haung Qi.,...&Jia Qi.(2014).Alkaloids from lotus leaf and related bioactivities.Chinese Traditional Patent Medicine,36(11),2330-2333.
MLA	Yuan Pulong,et al."Alkaloids from lotus leaf and related bioactivities".Chinese Traditional Patent Medicine 36.11(2014):2330-2333.