ADVANCE IN THE STUDY OF THE MECHANISMS REGULATED BY SPHINGOSINE-1-PHOSPHATE

	ADVANCE IN THE STUDY OF THE MECHANISMS REGULATED BY SPHINGOSINE-1-PHOSPHATE
	Ye Fei; Kong Xiangqian; Luo Cheng
刊名	Bulletin of National Natural Science Foundation of China
	2010
卷号	24 期号:5 页码:279-282
关键词	SlP SphKl SphK2 HDAC TRAF2 SIP SphKl SphK2 HDAC TRAF2 NF-KB signaling pathway
ISSN号	1000-8217
其他题名	鞘氨醇磷酸酯调控机制的研究进展
文献子类	Review
英文摘要	Sphingosine-l-phosphate(SIP)is a bioactive lipid messenger in the cells that regulate gene expression and NF-KB signal pathway through unknown mechanisms. Recentlv, Cheng Luo, Associate Professor of DDDC in Shanghai Institute of Materia Medica, whose project was funded by the National Natural Science Foundation of China, joined in a research team led by Professor Sarah Spiegel of Virginia Commonwealth University. The team continuously made significant breakthroughs in understanding the regulation mechanism of Sphingosine-l-Phosphate. In September 2009, in a paper published on Science magazine(Science, 2009, 325:1254-1257), they firstly demonstrated that SIP is a physi.ologically important regulator of histone deacetylases(HDACs), HDACs are direct intracellular targets of SIP. Furthermore, they identified the mechanism that SIP regulates gene expression through regulating the activity of HDACs.In June 24th, 2010, in another paper to be published on Nature magazine(Nature, 2010, June 24th, advance online publication, doi:10.1038/nature09128)which reports the regulation of NF-KB signaling pathway by SIP. They demonstrate that SIP is the missing cofactor for TRAF2(tumour-necrosis factor receptor-associated factor 2)and indicate a new paradigm for the regulation of lysine-63-linked poly-ubiquitination. The study also highlight the key role of SphKl and its product SIP in TNF-a signalling and the canonical NF-KB activation pathway, and then play crucial role in inflammatory, antiapoptotic and immune processes. The identification of new mechanisms by which SIP regulates gene expression and TNF and NF-KB signaling pathway will light up the road to develop novel inhibitors that might be useful for treatment of cancer and inflammatory diseases
WOS研究方向	Science & Technology - Other Topics (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:3988454
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267926]
专题	中国科学院上海药物研究所
作者单位	Drug Discovery and Design Center(DDDC), State Key Laboratory of Drug Research, Shanl, hai Institute of Materza Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Ye Fei,Kong Xiangqian,Luo Cheng. ADVANCE IN THE STUDY OF THE MECHANISMS REGULATED BY SPHINGOSINE-1-PHOSPHATE[J]. Bulletin of National Natural Science Foundation of China,2010,24(5):279-282.
APA	Ye Fei,Kong Xiangqian,&Luo Cheng.(2010).ADVANCE IN THE STUDY OF THE MECHANISMS REGULATED BY SPHINGOSINE-1-PHOSPHATE.Bulletin of National Natural Science Foundation of China,24(5),279-282.
MLA	Ye Fei,et al."ADVANCE IN THE STUDY OF THE MECHANISMS REGULATED BY SPHINGOSINE-1-PHOSPHATE".Bulletin of National Natural Science Foundation of China 24.5(2010):279-282.