Progress in the fragment-based drug discovery

	Progress in the fragment-based drug discovery
	Ren, Jing; Li, Jian; Shi, Feng; Wang, Xin; He, Jian-Hua; Xu, Ye-Chun; Zhang, Nai-Xia; Xiong, Bing; Shen, Jing-Kang
	2013-01
卷号	48
期号	1
页码	14-24
英文摘要	As an extension of the structure-based drug discovery, fragment-based drug discovery is matured increasingly, and plays an important role in drug development. Fragments in a small library, with lower molecular mass and high "ligand efficiency", are detected by SPR, MS, NMR, X-ray crystallography technologies and other biophysical methods. Then they are considered as starting points for chemical optimization with the guidance of structural biology methods to get good "drug-like" lead and candidate compounds. In this article, we reviewed the current progress of fragment-based drug discovery and detailed a number of examples to illustrate the novel strategies.
会议录	Yao xue xue bao = Acta pharmaceutica Sinica
文献子类	Meeting Abstract;Article;Review
语种	中文
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266883]
专题	中国科学院上海药物研究所
作者单位	State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Ren, Jing,Li, Jian,Shi, Feng,et al. Progress in the fragment-based drug discovery[C]. 见:.