New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana

doi:10.3390/md15040120

	New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana
	Tian, Xiang-Rong 3; Gao, Yan-Qing 3; Tian, Xiao-Lin 3; Li, Jiao 4; Tang, Hai-Feng 5; Li, Yu-Shan 1; Lin, Hou-Wen 2; Ma, Zhi-Qing 3
刊名	Marine drugs
	2017-04-13
卷号	15 期号:4
ISSN号	1660-3397
DOI	10.3390/md15040120
文献子类	Article
英文摘要	A new sterol, (23)-methoxycholest-5,24-dien-3β-ol (), two new ceramides, (2,3,4,8)-2-(tetradecanoylamino)-4,8-octadecadien-l,3-diol () and (2,3,2',4,8)-2-(tetradecanoylamino)-4,8-octadecadien-l,3,2'-triol (), together with three known sterols (-), a lactone () and two ceramides (,), were isolated from the marine bryozoan , collected at Huang Island of China. The structures of the new compounds were elucidated by extensive spectroscopic analyses, chemical methods and quantum electronic circular dichroism (ECD) calculations. Among the isolated compounds, sterol possessed a rare side chain with a methoxy group at C-23, and a double bond between C-24 and C-25. Ceramides and possessed 14 carbons in their long-chain fatty acid base (FAB), which were different from the normal ceramides with 16 carbons in the FAB. Moreover, compounds and were isolated for the first time from marine bryozoans. Compounds - were evaluated for their cytotoxicity against human tumor cell lines HL-60, Hep-G2 and SGC-7901. The results showed that lactone appears to have strong cytotoxicity against the test tumor cell lines, with IC values from 4.12 μM to 7.32 μM, and sterol displayed moderate cytotoxicity with IC values between 12.34 μM and 18.37 μM, while ceramides - showed weak cytotoxicity with IC ranging from 21.13 μM to 58.15 μM.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266737]
专题	中国科学院上海药物研究所
通讯作者	Tian, Xiang-Rong; Gao, Yan-Qing; Tian, Xiao-Lin; Li, Jiao; Tang, Hai-Feng; Li, Yu-Shan; Lin, Hou-Wen; Ma, Zhi-Qing
作者单位	1.School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China; 2.Department of Pharmacy, Renji Hospital, Affiliated to School of Medicine, Shanghai Jiao-Tong University, Shanghai 200127, China 3.Research & Development Center of Biorational Pesticide, Northwest A&F University, Yangling 712100, China; 4.State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China; 5.Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China;
推荐引用方式 GB/T 7714	Tian, Xiang-Rong,Gao, Yan-Qing,Tian, Xiao-Lin,et al. New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana[J]. Marine drugs,2017,15(4).
APA	Tian, Xiang-Rong.,Gao, Yan-Qing.,Tian, Xiao-Lin.,Li, Jiao.,Tang, Hai-Feng.,...&Ma, Zhi-Qing.(2017).New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana.Marine drugs,15(4).
MLA	Tian, Xiang-Rong,et al."New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana".Marine drugs 15.4(2017).