Effects of guan-fu base a on experimental cardiac arrhythmias and myocardial contractility

	Effects of guan-fu base a on experimental cardiac arrhythmias and myocardial contractility
	Dong, Y L; Chen, W Z
刊名	Yao xue xue bao = Acta pharmaceutica Sinica
	1995
卷号	30 期号:8 页码:577-82
ISSN号	0513-4870
文献子类	Article
英文摘要	Guan-fu base A (GFA) is a terpenoid alkaloid isolated from the tuber of Aconitum coreanum in our institute. GFA (20-30 mg.L-1) reduced the ventricular tachycardia (VT) and ventricular fibrillation (VF) rate induced by K(+)-free and high Ca2+ solution in Langendorf heart of rats. Pretreatment of conscious rats with GFA 2.5-10 mg.kg-1 iv, increased the amount of beiwutine necessary to produce arrhythmias. Ouabain-induced VT in conscious dogs was reverted to sinus rhythm in 1-2 min by iv GFA 9-10 mg.kg-1. GFA 10-20 mg.kg-1 iv was also found to be effective in protecting anesthetized dogs from atrial fibrillation induced by topical application of ACh. GFA 10 mg.kg-1 iv obviously decreased heart rate and prolonged the P-R interval, but slightly affected the myocardial contractility in anesthetized dogs. GFA showed no obvious effect on stroke volume and cardiac output in conscious dogs. In conclusion, GFA showed therapeutic and prophylactic effect on different models of experimental arrhythmias without causing marked effect on myocardial contractility.
语种	中文
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266663]
专题	中国科学院上海药物研究所
作者单位	Shanghai Institute of Materia Medica, Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Dong, Y L,Chen, W Z. Effects of guan-fu base a on experimental cardiac arrhythmias and myocardial contractility[J]. Yao xue xue bao = Acta pharmaceutica Sinica,1995,30(8):577-82.
APA	Dong, Y L,&Chen, W Z.(1995).Effects of guan-fu base a on experimental cardiac arrhythmias and myocardial contractility.Yao xue xue bao = Acta pharmaceutica Sinica,30(8),577-82.
MLA	Dong, Y L,et al."Effects of guan-fu base a on experimental cardiac arrhythmias and myocardial contractility".Yao xue xue bao = Acta pharmaceutica Sinica 30.8(1995):577-82.