Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation

doi:10.1016/j.ajpath.2018.04.015

	Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation
	Li, Yuan 2; Chao, Xiaojuan 2; Yang, Li 1; Lu, Qian 1; Li, Tiangang 2; Ding, Wen-Xing 2; Ni, Hong-Min 2
刊名	The American journal of pathology
	2018-08
卷号	188 期号:8 页码:1833-1846
ISSN号	1525-2191
DOI	10.1016/j.ajpath.2018.04.015
文献子类	Article
英文摘要	Lipid droplets (LDs) are intracellular organelles that store neutral lipids as energy reservoir. Recent studies suggest that autophagy is important in maintaining the homeostasis of intracellular LDs by either regulating the biogenesis of LDs, mobilization of fatty acids, or degradation of LDs in cultured cells. Increasing evidence also supports a role of autophagy in regulating glucose and lipid metabolism in vivo in mammals. In response to fasting/starvation, lipids are mobilized from the adipose tissue to the liver, which increases the number of intracellular LDs and stimulates fatty acid oxidation and ketogenesis. However, it is still controversial and unclear how impaired autophagy in hepatocytes affects the biogenesis of LDs in mouse livers. In the present study, it was demonstrated that hepatic autophagy-deficient (L-Atg)5 knockout mice had impaired adaptation to fasting-induced hepatic biogenesis of LDs. The maladaptation to fasting-induced hepatic biogenesis of LDs in L-Atg5 knockout mouse livers was not due to hepatic changes of de novo lipogenesis, secretion of very-low-density lipoprotein or fatty acid β-oxidation, but it was due to persistent nuclear factor-like 2 activation because biogenesis of LDs restored in L-Atg5/nuclear factor-like 2 double-knockout mice.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266622]
专题	中国科学院上海药物研究所
通讯作者	Ding, Wen-Xing; Ni, Hong-Min
作者单位	1.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China 2.Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas;
推荐引用方式 GB/T 7714	Li, Yuan,Chao, Xiaojuan,Yang, Li,et al. Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation[J]. The American journal of pathology,2018,188(8):1833-1846.
APA	Li, Yuan.,Chao, Xiaojuan.,Yang, Li.,Lu, Qian.,Li, Tiangang.,...&Ni, Hong-Min.(2018).Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation.The American journal of pathology,188(8),1833-1846.
MLA	Li, Yuan,et al."Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation".The American journal of pathology 188.8(2018):1833-1846.