Modeling the three stages in HIV infection

doi:10.1016/j.jtbi.2012.11.028

	Modeling the three stages in HIV infection
	Hernandez-Vargas, Esteban A; Middleton, Richard H
刊名	Journal of theoretical biology
	2013-03-07
卷号	320 页码:33-40
ISSN号	1095-8541
DOI	10.1016/j.jtbi.2012.11.028
文献子类	Article
英文摘要	A typical HIV infection response consists of three stages: an initial acute infection, a long asymptomatic period and a final increase in viral load with simultaneous collapse in healthy CD4+T cell counts. The majority of existing mathematical models give a good representation of either the first two stages or the last stage of the infection. Using macrophages as a long-term active reservoir, a deterministic model is proposed to explain the three stages of the infection including the progression to AIDS. Simulation results illustrate how chronic infected macrophages can explain the progression to AIDS provoking viral explosion. Further simulation studies suggest that the proposed model retains its key properties even under moderately large parameter variations. This model provides important insights on how macrophages might play a crucial role in the long term behavior of HIV infection.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266548]
专题	中国科学院上海药物研究所
作者单位	SIMM, Helmholtz Zentrum für Infektionsforschung, Inhoffenstraße 7, D-38124 Braunschweig, Germany
推荐引用方式 GB/T 7714	Hernandez-Vargas, Esteban A,Middleton, Richard H. Modeling the three stages in HIV infection[J]. Journal of theoretical biology,2013,320:33-40.
APA	Hernandez-Vargas, Esteban A,&Middleton, Richard H.(2013).Modeling the three stages in HIV infection.Journal of theoretical biology,320,33-40.
MLA	Hernandez-Vargas, Esteban A,et al."Modeling the three stages in HIV infection".Journal of theoretical biology 320(2013):33-40.