The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis

doi:10.1152/ajpgi.00133.2015

	The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis
	Ren, Gaiyan 1,3; Sun, Aning 1,3; Deng, Chao 1,3; Zhang, Jingjing 1,3; Wu, Xiaojun 1,3; Wei, Xiaohui 1,3; Mani, Sridhar 4; Dou, Wei 2,3; Wang, Zhengtao 1,3
刊名	American journal of physiology. Gastrointestinal and liver physiology
	2015-10-01
卷号	309 期号:7 页码:G517-27
ISSN号	1522-1547
DOI	10.1152/ajpgi.00133.2015
文献子类	Article
英文摘要	Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. However, the direct effect of cardamonin on intestinal inflammation remains elusive. In the present study, we found that cardamonin markedly ameliorated dextran sulfate sodium-induced mouse body weight loss, diarrhea, colon shortening, spleen swelling, and histological damage, which correlated with a decline in the activity of myeloperoxidase and the production of nitric oxide, tumor necrosis factor-α and interleukin-6 in the colon. The upregulation of toll-like receptor 4 after dextran sulfate sodium treatment was associated with an increase in the activation of myeloid differentiation factor 88, interleukin-1 receptor-associated kinase-1, nuclear factor-κB (NF-κB) p65, inhibitor κBα, and inhibitor κB kinase-α/β, as well as the mitogen-activated protein kinase molecules of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase, and this upregulation was reversed by cardamonin administration. Moreover, cardamonin blocked the nuclear translocation of NF-κB p65, inhibited NF-κB-luciferase activity, and downregulated NF-κB target genes expression. The present study clearly demonstrates a beneficial effect of cardamonin on experimental inflammatory bowel disease via a mechanism associated with suppression of toll-like receptor 4 expression and inactivation of NF-κB and mitogen-activated protein kinase pathways. This study may give insight into the further evaluation of the therapeutic potential of cardamonin or its derivatives for human inflammatory bowel disease.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266474]
专题	中国科学院上海药物研究所
通讯作者	Dou, Wei
作者单位	1.and; 2.and vivi 3.Shanghai Key Laboratory of Complex Prescription and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 4.Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, New York;
推荐引用方式 GB/T 7714	Ren, Gaiyan,Sun, Aning,Deng, Chao,et al. The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis[J]. American journal of physiology. Gastrointestinal and liver physiology,2015,309(7):G517-27.
APA	Ren, Gaiyan.,Sun, Aning.,Deng, Chao.,Zhang, Jingjing.,Wu, Xiaojun.,...&Wang, Zhengtao.(2015).The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis.American journal of physiology. Gastrointestinal and liver physiology,309(7),G517-27.
MLA	Ren, Gaiyan,et al."The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis".American journal of physiology. Gastrointestinal and liver physiology 309.7(2015):G517-27.