Astragaloside IV regulates differentiation and induces apoptosis of activated CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis

doi:10.1016/j.taap.2018.10.024

	Astragaloside IV regulates differentiation and induces apoptosis of activated CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis
	Yang, Liu; Xing, Faping; Han, Xinyan; Li, Qi; Wu, Hui; Shi, Hailian; Wang, Zhifei; Huang, Fei; Wu, Xiaojun
刊名	Toxicology and applied pharmacology
	2019
卷号	362 页码:105-115
ISSN号	1096-0333
DOI	10.1016/j.taap.2018.10.024
文献子类	Article
英文摘要	CD4 T cells, especially T-helper (Th) cells (Th1, Th2 and Th17) and regulatory T cells (Treg) play pivotal role in the pathogenesis of multiple sclerosis (MS), a demyelinating autoimmune disease occurring in central nervous system (CNS). Astragaloside IV (ASI, CAS: 84687-43-4) is one of the saponins isolated from Astragalus membranceus, a traditional Chinese medicine with immunomodulatory effect. So far, whether ASI has curative effect on experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and how it affects the subsets of CD4 T cells, as well as the underlying mechanism have not been clearly elucidated. In the present study, ASI was found to ameliorate the progression and hamper the recurrence of EAE effectively in the treatment regimens. It significantly reduced the demyelination and inflammatory infiltration of CNS in EAE mice by suppressing the percentage of Th1 and Th17 cells, which was closely associated with the inhibition of JAK/STAT and NF-κB signaling pathways. ASI also increased the percentage of Treg cells in spleen and CNS, which was accompanied by elevated Foxp3. However, in vitro experiments disclosed that ASI could regulate the differentiation of Th17 and Treg cells but not Th1 cells. In addition, it induced the apoptosis of MOG-stimulated CD4 T cells probably through modulating STAT3/Bcl-2/Bax signaling pathways. Together, our findings suggested that ASI can modulate the differentiation of autoreactive CD4 T cells and is a potential prodrug or drug for the treatment of MS and other similar autoimmune diseases.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266445]
专题	中国科学院上海药物研究所
通讯作者	Huang, Fei; Wu, Xiaojun
作者单位	Shanghai Key Laboratory of Compound Chinese Medicines, the Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
推荐引用方式 GB/T 7714	Yang, Liu,Xing, Faping,Han, Xinyan,et al. Astragaloside IV regulates differentiation and induces apoptosis of activated CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis[J]. Toxicology and applied pharmacology,2019,362:105-115.
APA	Yang, Liu.,Xing, Faping.,Han, Xinyan.,Li, Qi.,Wu, Hui.,...&Wu, Xiaojun.(2019).Astragaloside IV regulates differentiation and induces apoptosis of activated CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis.Toxicology and applied pharmacology,362,105-115.
MLA	Yang, Liu,et al."Astragaloside IV regulates differentiation and induces apoptosis of activated CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis".Toxicology and applied pharmacology 362(2019):105-115.