Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice

doi:10.18632/aging.101145

	Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice
	Xu, Ying 2; Chen, Ting 2; Li, Xin 2; Qu, Ya-Kun 2; An, Jin-Na 2; Zheng, Hong-Xia 2; Zhang, Zi-Jia 1; Lin, Na 2
刊名	Aging
	2016-12-20
卷号	9 期号:1 页码:156-172
ISSN号	1945-4589
DOI	10.18632/aging.101145
文献子类	Article
英文摘要	Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using models of immature and ovariectomized (OVX) mice and performed studies focusing on the estrogen receptor (ER) pathway for further molecular characterizations. SM treatments demonstrated significant estrogenic activity by promoting the development of uterus and vagina in immature mice, restoring the estrus cycle and reversing the atrophy of reproductive tissues in OVX mice, as well as increasing the expressions of ERα and ERβ at protein and mRNA level in the reproductive tissues. Meanwhile, SM significantly increased estradiol in serum, and decreased follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the circulation of immature and OVX mice. SM could stimulate the binding effect of ERα and ERβ, and significantly induce ERα/β-estrogen response element (ERE) luciferase reporter gene expression. All these activities were inhibited by the ER antagonist ICI182, 780. This study demonstrates SM exerts estrogenic effects by stimulating biosynthesis of estrogen and increasing ERs in target tissues without side effects on reproductive tissues and through ER-ERE-dependent pathway.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266399]
专题	中国科学院上海药物研究所
作者单位	1.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 100101, China 2.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
推荐引用方式 GB/T 7714	Xu, Ying,Chen, Ting,Li, Xin,et al. Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice[J]. Aging,2016,9(1):156-172.
APA	Xu, Ying.,Chen, Ting.,Li, Xin.,Qu, Ya-Kun.,An, Jin-Na.,...&Lin, Na.(2016).Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice.Aging,9(1),156-172.
MLA	Xu, Ying,et al."Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice".Aging 9.1(2016):156-172.