Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells

doi:10.3892/or.2016.4931

	Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells
	Zhu, Lei 2; Tian, Guangang 2; Yang, Qin 2; De, Gejing 1; Zhang, Zhigang 2; Wang, Yahui 2; Nie, Huizhen 2; Zhang, Yanli 2; Yang, Xiaomei 2; Li, Jun2
刊名	Oncology reports
	2016-09
卷号	36 期号:3 页码:1419-26
ISSN号	1791-2431
DOI	10.3892/or.2016.4931
文献子类	Article
英文摘要	Thyroid hormone receptor β1 (TRβ1) is a ligand‑dependent transcription factor that belongs to the superfamily of nuclear receptors. TRβ1 has been found to act as a tumor suppressor in many solid tumors including breast cancer and hepatocellular carcinoma, but its role in the progression of human colorectal cancer (CRC) remains unclear. In this study, microarray data analysis revealed that TRβ1 mRNA was downregulated in CRC tumors compared with that in the normal counterparts in both The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Using a CRC tissue microarray (TMA), we confirmed that the expression of TRβ1 was decreased in human CRC tumor tissues in contrast to normal colorectal mucosal tissues. Notably, the TRβ1 expression was strongly correlated with tumor size (p=0.045). Furthermore, we found that CRC cell proliferation and migration were significantly inhibited by TRβ1 overexpression in vitro. Mechanistic studies indicated that activated phosphorylated Akt was clearly suppressed by TRβ1 in the CRC tissues and cells. In conclusion, this study provides evidence that TRβ1 plays a critical role in the progression of CRC via the PI3K/Akt pathway, and the TRβ1 gene may represent a novel target for CRC therapeutics.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266378]
专题	中国科学院上海药物研究所
作者单位	1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100050, P.R. China 2.State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, P.R. China;
推荐引用方式 GB/T 7714	Zhu, Lei,Tian, Guangang,Yang, Qin,et al. Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells[J]. Oncology reports,2016,36(3):1419-26.
APA	Zhu, Lei.,Tian, Guangang.,Yang, Qin.,De, Gejing.,Zhang, Zhigang.,...&Li, Jun.(2016).Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells.Oncology reports,36(3),1419-26.
MLA	Zhu, Lei,et al."Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells".Oncology reports 36.3(2016):1419-26.