Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy

doi:10.7150/thno.33472

	Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy
	Zhang, Qiuhong; Chen, Jingwen; Shen, Jie; Chen, Shixiong; Liang, Kaicheng; Wang, Han; Chen, Hangrong
刊名	THERANOSTICS
	2019
卷号	9 期号:10 页码:2779
关键词	ferritin radiotherapy chemotherapy polypeptide subunit bismuth sulfide
ISSN号	1838-7640
DOI	10.7150/thno.33472
文献子类	Article
英文摘要	Rationale: Ferritin with unique hollow cavity is an emerging protein-based nanoplatform for anticancer-drug delivery, but the in vivo chemotherapeutic effectiveness is still unsatisfactory with such a monotherapy modality, which is urgently in need of improvement. Methods: Here a novel ferritin nanotheranostic with anticancer-drug doxorubicin encapsulated into its hollow interior and nanoradiosensitizer bismuth sulfide nanocrystals inlayed onto its polypeptide shell was synthesized for combinational therapeutic benefits. The formation mechanism of bismuth sulfide nanocrystals based on ferritin has been analyzed. The in vitro and in vivo treatment effects were carried out on HeLa cancer cells and tumor-bearing mice, respectively. The biocompatibility and excretion of the ferritin nanotheranostic have also been evaluated to guarantee their biosafety. Results: The polypeptide shell of ferritin provides nucleation sites for the bismuth sulfide nanocrystals through coordination interaction, and simultaneously inhibits the further growth of bismuth sulfide nanocrystals, rendering the bismuth sulfide nanocrystals like rivets inlaying onto the polypeptide firmly, which can not only strengthen the architectural stability of ferritin to prevent drug burst leakage during systemic circulation, but also act as excellent computed tomography contrast agents and nanoradiosensitizers for in vivo imaging-guided cancer combinational treatments. Conclusions: The design concept of inlaying bismuth sulfide nanocrystals onto the polypeptide shell of doxorubicin-encapsulated ferritin significantly inhibits the tumor growth and simultaneously further broadens the application of ferritin in nanomedicine.
WOS研究方向	Research & Experimental Medicine
语种	英语
出版者	IVYSPRING INT PUBL
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27415]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Zhang, Qiuhong,Chen, Jingwen,Shen, Jie,et al. Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy[J]. THERANOSTICS,2019,9(10):2779.
APA	Zhang, Qiuhong.,Chen, Jingwen.,Shen, Jie.,Chen, Shixiong.,Liang, Kaicheng.,...&Chen, Hangrong.(2019).Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy.THERANOSTICS,9(10),2779.
MLA	Zhang, Qiuhong,et al."Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy".THERANOSTICS 9.10(2019):2779.