Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow

doi:10.1021/acs.nanolett.9b00364

	Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow
	Zhu, Piao; Gao, Shanshan; Lin, Han; Lu, Xiangyu; Yang, Bowen; Zhang, Linlin; Chen, Yu; Shi, Jianlin
刊名	NANO LETTERS
	2019-03-01
卷号	19 期号:3 页码:2128
关键词	Liquid metal photothermal therapy NIR-II targeted nanomedicine cancer
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.9b00364
文献子类	Article
英文摘要	Gallium and gallium-based alloys, typical types of liquid metals with unique physiochemical properties, are emerging as a next generation of functional materials in versatile biomedical applications. However, the exploration of their biomedical performance is currently insufficient, and their intrinsic low oxidative resistance is a key factor blocking their further clinical translation. Herein, we report on the surface engineering of liquid metal-based nanoplatforms by an inorganic silica nanoshell based on a novel but facile sonochemical synthesis for highly efficient, targeted, and near-infrared (NIR)-triggered photothermal tumor hyperthermia in the NIR-II biowindow. The inorganic silica-shell engineering of liquid metal significantly enhances the photothermal performance of the liquid metal core as reflected by enhanced NIR absorption, improved photothermal stability by oxidation protection, and abundant surface chemistry for surface-targeted engineering to achieve enhanced tumor accumulation. Systematic in vitro cell-level evaluation and in vivo tumor xenograft assessment demonstrate that (Arg-Gly-Asp) RGD-targeted and silica-coated nanoscale liquid metal substantially induces phototriggered cancer-cell death and photothermal tumor eradication, accompanied by high in vivo biocompatibility and easy excretion out of the body. This work provides the first paradigm for surface-inorganic engineering of liquid metal-based nanoplatforms for achieving multiple desirable therapeutic performances, especially for combating cancer.
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27300]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Zhu, Piao,Gao, Shanshan,Lin, Han,et al. Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow[J]. NANO LETTERS,2019,19(3):2128.
APA	Zhu, Piao.,Gao, Shanshan.,Lin, Han.,Lu, Xiangyu.,Yang, Bowen.,...&Shi, Jianlin.(2019).Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow.NANO LETTERS,19(3),2128.
MLA	Zhu, Piao,et al."Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow".NANO LETTERS 19.3(2019):2128.