Breaking the Depth Dependence by Nanotechnology-Enhanced X-Ray-Excited Deep Cancer Theranostics

doi:10.1002/adma.201806381

	Breaking the Depth Dependence by Nanotechnology-Enhanced X-Ray-Excited Deep Cancer Theranostics
	Fan, Wenpei; Tang, Wei; Lau, Joseph; Shen, Zheyu; Xie, Jin; Shi, Jianlin; Chen, Xiaoyuan
刊名	ADVANCED MATERIALS
	2019-03-22
卷号	31 期号:12
关键词	deep theranostics nanomaterials nanotechnology synchronous synergistic therapy X-ray radiation
ISSN号	0935-9648
DOI	10.1002/adma.201806381
文献子类	Review
英文摘要	The advancements in nanotechnology have created multifunctional nanomaterials aimed at enhancing diagnostic accuracy and treatment efficacy for cancer. However, the ability to target deep-seated tumors remains one of the most critical challenges for certain nanomedicine applications. To this end, X-ray-excited theranostic techniques provide a means of overcoming the limits of light penetration and tissue attenuation. Herein, a comprehensive overview of the recent advances in nanotechnology-enhanced X-ray-excited imaging and therapeutic methodologies is presented, with an emphasis on the design of multifunctional nanomaterials for contrast-enhanced computed tomography (CT) imaging, X-ray-excited optical luminescence (XEOL) imaging, and X-ray-excited multimodal synchronous/synergistic therapy. The latter is based on the concurrent use of radiotherapy with chemotherapy, gas therapy, photodynamic therapy, or immunotherapy. Moreover, the featured biomedical applications of X-ray-excited deep theranostics are discussed to highlight the advantages of X-ray in high-sensitivity detection and efficient elimination of malignant tumors. Finally, key issues and technical challenges associated with this deep theranostic technology are identified, with the intention of advancing its translation into the clinic.
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27261]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Fan, Wenpei,Tang, Wei,Lau, Joseph,et al. Breaking the Depth Dependence by Nanotechnology-Enhanced X-Ray-Excited Deep Cancer Theranostics[J]. ADVANCED MATERIALS,2019,31(12).
APA	Fan, Wenpei.,Tang, Wei.,Lau, Joseph.,Shen, Zheyu.,Xie, Jin.,...&Chen, Xiaoyuan.(2019).Breaking the Depth Dependence by Nanotechnology-Enhanced X-Ray-Excited Deep Cancer Theranostics.ADVANCED MATERIALS,31(12).
MLA	Fan, Wenpei,et al."Breaking the Depth Dependence by Nanotechnology-Enhanced X-Ray-Excited Deep Cancer Theranostics".ADVANCED MATERIALS 31.12(2019).