Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection

doi:10.1002/adma.201902956

	Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection
	Ni, Dalong; Wei, Hao; Chen, Weiyu; Bao, Qunqun; Rosenkrans, Zachary T.; Barnhart, Todd E.; Ferreira, Carolina A.; Wang, Yanpu; Yao, Heliang; Sun, Tuanwei
刊名	ADVANCED MATERIALS
	2019-08-01
卷号	31 期号:40
关键词	acute livery injury ceria nanoparticles hepatic ischemia-reperfusion injury nano-antixoidants reactive oxygen species
ISSN号	0935-9648
DOI	10.1002/adma.201902956
文献子类	Article
英文摘要	The mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a "blackbox" by nanoresearchers in translating nanomedicines. Often, most of the injected nanomaterials are sequestered by the MPS, preventing their delivery to the desired disease areas. Here, this imperfection is exploited by applying nano-antioxidants with preferential liver uptake to directly prevent hepatic ischemia-reperfusion injury (IRI), which is a reactive oxygen species (ROS)-related disease. Ceria nanoparticles (NPs) are selected as a representative nano-antioxidant and the detailed mechanism of preventing IRI is investigated. It is found that ceria NPs effectively alleviate the clinical symptoms of hepatic IRI by scavenging ROS, inhibiting activation of Kupffer cells and monocyte/macrophage cells. The released pro-inflammatory cytokines are then significantly reduced and the recruitment and infiltration of neutrophils are minimized, which suppress subsequent inflammatory reaction involved in the liver. The protective effect of nano-antioxidants against hepatic IRI in living animals and the revealed mechanism herein suggests their future use for the treatment of hepatic IRI in the clinic.
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26902]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Ni, Dalong,Wei, Hao,Chen, Weiyu,et al. Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection[J]. ADVANCED MATERIALS,2019,31(40).
APA	Ni, Dalong.,Wei, Hao.,Chen, Weiyu.,Bao, Qunqun.,Rosenkrans, Zachary T..,...&Cai, Weibo.(2019).Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection.ADVANCED MATERIALS,31(40).
MLA	Ni, Dalong,et al."Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection".ADVANCED MATERIALS 31.40(2019).