A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection

doi:10.1016/j.biomaterials.2019.119372

	A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection
	Lin, Zhengjie; Zhao, Ying; Chu, Paul K.; Wang, Luning; Pan, Haobo; Zheng, Yufeng; Wu, Shuilin; Liu, Xuanyong; Cheung, Kenneth M. C.; Wong, Takman
刊名	BIOMATERIALS
	2019-10-01
卷号	219
关键词	Titanium oxide nano-layer Biodegradable mg Corrosion resistance Bone regeneration Bacteria disinfection
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2019.119372
文献子类	Article
英文摘要	Rapid corrosion of biodegradable magnesium alloys under in vivo condition is a major concern for clinical applications. Inspired by the stability and biocompatibility of titanium oxide (TiO2) passive layer, a functionalized TiO2/Mg2TiO4 nano-layer has been constructed on the surface of WE43 magnesium implant by using plasma ion immersion implantation (PIII) technique. The customized nano-layer not only enhances corrosion resistance of Mg substrates significantly, but also elevates the osteoblastic differentiation capability in vitro due to the controlled release of magnesium ions. In the animal study, the increase of new bone formation adjacent to the PIII-treated magnesium substrate is 175% higher at post-operation 12 weeks, whereas the growth of new bone on titanium control and untreated magnesium substrate are only 97% and 29%, respectively. In addition, its Young's modulus can be restored to about 82% as compared with the surrounding matured bone. Furthermore, this specific TiO2/Mg2TiO4 layer even exhibits photoactive bacteria disinfection capability when irradiated by ultraviolet light which is attributed to the intracellular reactive oxygen species (ROS) production. With all these constructive observations, it is believed that the TiO2/Mg2TiO4 nano-layer on magnesium implants can significantly promote new bone formation and suppress bacterial infection, while the degradation behavior can be controlled simultaneously.
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26797]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Lin, Zhengjie,Zhao, Ying,Chu, Paul K.,et al. A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection[J]. BIOMATERIALS,2019,219.
APA	Lin, Zhengjie.,Zhao, Ying.,Chu, Paul K..,Wang, Luning.,Pan, Haobo.,...&Yeung, Kelvin W. K..(2019).A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection.BIOMATERIALS,219.
MLA	Lin, Zhengjie,et al."A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection".BIOMATERIALS 219(2019).