A pH-sensitive polymer based precise tumor targeting strategy with reduced uptake of nanoparticles by non-cancerous cells

doi:10.1039/c9tb01202h

	A pH-sensitive polymer based precise tumor targeting strategy with reduced uptake of nanoparticles by non-cancerous cells
	Li, Zihou; Ma, Xuehua; Xia, Yuanzhi; Qian, Kun; Akakuru, Ozioma Udochukwu; Luo, Lijia; Zheng, Jianjun; Cui, Ping; Shen, Zheyu; Wu, Aiguo
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2019-10-21
卷号	7 期号:39 页码:5983
ISSN号	2050-750X
DOI	10.1039/c9tb01202h
文献子类	Article
英文摘要	Drug-loaded nanoparticles can be specifically uptaken by tumor cells to realize active targeting due to the conjugated ligands or antibodies on their surface. However, some non-cancerous cells express non-specific receptors or antigens on their surface, which can react with the ligands or antibodies conjugated on the nanoparticle surface and then result in non-specific uptake of the nanoparticles by non-cancerous cells. In order to reduce the non-specific uptake of nanoparticles by non-cancerous cells, in this study, we proposed a pH-sensitive polymer based precise tumor targeting strategy and synthesized superparamagnetic iron oxide nanoparticle (SPION) encapsulated albumin nanoparticles (AN) with conjugation of folic acid (FA) and mPEG-DCA (SPION-AN-FA@mPEG), in which mPEG can shield FA, avoiding the non-specific recognition by normal cells under physiological conditions, and can be shed to expose FA in tumor microenvironments. The pH-sensitivity of mPEG-DCA was verified by HPLC characterization and H-1-NMR spectroscopy. The graft density and length of mPEG-DCA were optimized via the cellular uptake of SPION-AN-FA@mPEG measured by flow cytometry analysis. The r(2) value and r(2)/r(1) ratio of the optimized SPION-AN-FA@mPEG (i.e., SPION-AN-FA@mPEG4) are 168.6 mM(-1) s(-1) and 42.8, respectively, which are both much higher than that of the commercial contrast agent Resovist (R). The in vitro T-2-weighted MR images and in vivo MRI performance demonstrate that our SPION-AN-FA@mPEG4 nanoparticles can be used as an effective T-2-weighted MRI contrast agent.
WOS研究方向	Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26769]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Li, Zihou,Ma, Xuehua,Xia, Yuanzhi,et al. A pH-sensitive polymer based precise tumor targeting strategy with reduced uptake of nanoparticles by non-cancerous cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(39):5983.
APA	Li, Zihou.,Ma, Xuehua.,Xia, Yuanzhi.,Qian, Kun.,Akakuru, Ozioma Udochukwu.,...&Wu, Aiguo.(2019).A pH-sensitive polymer based precise tumor targeting strategy with reduced uptake of nanoparticles by non-cancerous cells.JOURNAL OF MATERIALS CHEMISTRY B,7(39),5983.
MLA	Li, Zihou,et al."A pH-sensitive polymer based precise tumor targeting strategy with reduced uptake of nanoparticles by non-cancerous cells".JOURNAL OF MATERIALS CHEMISTRY B 7.39(2019):5983.