Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT

doi:10.2214/AJR.18.20843

	Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT
	Yang, Zehong 2,3; Zhang, Xiang 2,3; Fang, Mengjie 4,5; Li, Guolin 1,3; Duan, Xiaohui 2,3; Mao, Jiaji 2,3; Shen, Jun 2,3
刊名	AMERICAN JOURNAL OF ROENTGENOLOGY
	2019-07-01
卷号	213 期号:1 页码:W17-W25
关键词	colorectal neoplasm diagnostic imaging lymphadenopathy MDCT
ISSN号	0361-803X
DOI	10.2214/AJR.18.20843
通讯作者	Shen, Jun(shenjun@mail.sysu.edu.cn)
英文摘要	OBJECTIVE. The purpose of this study was to investigate the performance of quantitative parameters derived from dual-energy CT (DECT) in the preoperative diagnosis of regional metastatic lymph nodes (LNs) in patients with colorectal cancer. SUBJECTS AND METHODS. Triphasic contrast-enhanced DECT was performed for 178 patients with colon or high rectal cancer. The morphologic criteria, short-axis diameter, and quantitative DECT parameters of the largest regional LN were measured and compared between pathologically metastatic and nonmetastatic LNs. Univariate and multivariable logistic regression analyses were used to determine the independent DECT parameters for predicting LN metastasis. Diagnostic performance measures were assessed by ROC curve analysis and compared by McNemar test. RESULTS. A total of 178 largest LNs (72 metastatic, 106 nonmetastatic) were identified in 178 patients. The best single DECT parameter for differentiation between metastatic and nonmetastatic LNs was normalized effective atomic number (Z(eff)) in the portal venous phase (AUC, 0.871; accuracy, 84.8%). These values were higher than those of morphologic criteria (AUC, 0.505-0.624; accuracy, 478-62.4%) and short-axis diameter (AUC, 0.647; accuracy, 66.3%) (p < 0.05). The diagnostic accuracy of combined normalized iodine concentration in the arterial phase and normalized effective atomic number in the portal venous phase was further improved to 871% (AUC, 0.916). CONCLUSION. Quantitative parameters derived from DECT can be used to improve preoperative diagnostic accuracy in evaluation for regional metastatic LNs in patients with colorectal cancer.
资助项目	Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme ; National Natural Science Foundation of China[81571739] ; National Natural Science Foundation of China[81371607] ; Guangdong Natural Science Foundation[2014A030312018] ; Guangdong Natural Science Foundation[2017A030313777] ; National Basic Research Program of China[2015CB755500] ; Elite Young Scholars Program of Sun Yat-Sen Memorial Hospital[J201403]
WOS关键词	COLON-CANCER ; COMPUTED-TOMOGRAPHY ; IODINE CONCENTRATION ; ADJUVANT THERAPY ; F-18-FDG PET ; SPECTRAL CT ; ACCURACY ; ANGIOGENESIS ; METAANALYSIS
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	AMER ROENTGEN RAY SOC
WOS记录号	WOS:000472493900003
资助机构	Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme ; National Natural Science Foundation of China ; Guangdong Natural Science Foundation ; National Basic Research Program of China ; Elite Young Scholars Program of Sun Yat-Sen Memorial Hospital
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/27854]
专题	中国科学院自动化研究所
通讯作者	Shen, Jun
作者单位	1.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Radiol, 107 Yanjiang Rd W, Guangzhou 510120, Guangdong, Peoples R China 3.Sun Yat Sen Univ, Sun Yet Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China 4.Chinese Acad Sci, Key Lab Mol Imaging, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Zehong,Zhang, Xiang,Fang, Mengjie,et al. Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT[J]. AMERICAN JOURNAL OF ROENTGENOLOGY,2019,213(1):W17-W25.
APA	Yang, Zehong.,Zhang, Xiang.,Fang, Mengjie.,Li, Guolin.,Duan, Xiaohui.,...&Shen, Jun.(2019).Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT.AMERICAN JOURNAL OF ROENTGENOLOGY,213(1),W17-W25.
MLA	Yang, Zehong,et al."Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT".AMERICAN JOURNAL OF ROENTGENOLOGY 213.1(2019):W17-W25.