Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons

doi:10.3389/fnins.2019.00565

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons
	Zhang, SH ; Lv, F ; Yuan, Y ; Fan, CY ; Li, J ; Sun, WZ ; Hu, J
刊名	FRONTIERS IN NEUROSCIENCE
	2019
卷号	13 期号:-页码:—
关键词	ANTERIOR CINGULATE CORTEX CORTICOTROPIN-RELEASING-FACTOR INTERNEURON DIVERSITY SERIES NUCLEUS BASALIS MOUSE MODEL SEROTONIN STRESS PAIN DORSAL DOPAMINE
ISSN号	1662-453X
DOI	10.3389/fnins.2019.00565
文献子类	期刊论文
英文摘要	Corticotropin-releasing hormone (CRH) is a critical neuropeptide modulating the mammalian stress response. It is involved in many functional activities within various brain regions, among which there is a subset of CRH neurons occupying a considerable proportion of the cortical GABAergic interneurons. Here, we utilized rabies virus-based monosynaptic retrograde tracing system to map the whole-brain afferent presynaptic partners of the CRH neurons in the anterior cingulate cortex (ACC). We find that the ACC CRH neurons integrate information from the cortex, thalamus, hippocampal formation, amygdala, and also several other midbrain and hindbrain nuclei. Furthermore, our results reveal that ACC CRH neurons receive direct inputs from two neuromodulatory systems, the basal forebrain cholinergic neurons and raphe serotoninergic neurons. These findings together expand our knowledge about the connectivity of the cortical GABAergic neurons and also provide a basis for further investigation of the circuit function of cortical CRH neurons.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31902]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; 5.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China; 6.Chinese Acad Sci, Inst Neurosci, Shanghai, Peoples R China; 7.Chinese Inst Brain Res, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, SH,Lv, F,Yuan, Y,et al. Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons[J]. FRONTIERS IN NEUROSCIENCE,2019,13(-):—.
APA	Zhang, SH.,Lv, F.,Yuan, Y.,Fan, CY.,Li, J.,...&Hu, J.(2019).Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.FRONTIERS IN NEUROSCIENCE,13(-),—.
MLA	Zhang, SH,et al."Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons".FRONTIERS IN NEUROSCIENCE 13.-(2019):—.