DNA Nanotechnology-Enabled Drug Delivery Systems

doi:10.1021/acs.chemrev.7b00663

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	DNA Nanotechnology-Enabled Drug Delivery Systems
	Hu, QQ ; Li, H ; Wang, LH ; Gu, HZ ; Fan, CH
刊名	CHEMICAL REVIEWS
	2019
卷号	119 期号:10 页码:6459—6506
关键词	BLOOD-BRAIN-BARRIER SINGLE-STRANDED-DNA RECEPTOR-MEDIATED ENDOCYTOSIS MESSENGER-RNA DETECTION NUCLEIC-ACID JUNCTIONS GOLD NANOPARTICLES ORIGAMI NANOSTRUCTURES INTRACELLULAR DELIVERY CELLULAR UPTAKE CO-DELIVERY
ISSN号	0009-2665
DOI	10.1021/acs.chemrev.7b00663
文献子类	期刊论文
英文摘要	Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity. Various sequence programming and optimization approaches have been developed to design DNA nanostructures with precisely engineered, controllable size, shape, surface chemistry, and function. Potent anticancer drug molecules, including Doxorubicin and CpG oligonucleotides, have been successfully loaded on DNA nanostructures to increase their cell uptake efficiency. These advances have implicated the bright future of DNA nanotechnology-enabled nano medicine. In this review, we begin with the origin of DNA nanotechnology, followed by summarizing state-of-the-art strategies for the construction of DNA nanostructures and drug payloads delivered by DNA nanovehicles. Further, we discuss the cellular fates of DNA nanostructures as well as challenges and opportunities for DNA nanostructure-based drug delivery.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31565]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Fudan Univ, Fudan Univ Shanghai Canc Ctr, Shanghai 200032, Peoples R China; 2.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China; 3.Fudan Univ, Sch Basic Med Sci, Dept Syst Biol Med, Shanghai 200032, Peoples R China; 4.Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai 200032, Peoples R China; 5.Shandong Buchang Pharmaceut Co Ltd, Res & Dev Ctr, Heze 274000, Peoples R China; 6.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China; 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 8.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China;
推荐引用方式 GB/T 7714	Hu, QQ,Li, H,Wang, LH,et al. DNA Nanotechnology-Enabled Drug Delivery Systems[J]. CHEMICAL REVIEWS,2019,119(10):6459—6506.
APA	Hu, QQ,Li, H,Wang, LH,Gu, HZ,&Fan, CH.(2019).DNA Nanotechnology-Enabled Drug Delivery Systems.CHEMICAL REVIEWS,119(10),6459—6506.
MLA	Hu, QQ,et al."DNA Nanotechnology-Enabled Drug Delivery Systems".CHEMICAL REVIEWS 119.10(2019):6459—6506.