Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies

doi:10.1021/jacs.8b04169

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies
	Lu, JX ; Sun, JH ; Li, FY ; Wang, J ; Liu, JN ; Kim, D ; Fan, CH ; Hyeon, T ; Ling, DS
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2018
卷号	140 期号:32 页码:10071-10074
关键词	RESONANCE-IMAGING CONTRAST NANOPARTICLES AGENTS DELIVERY PERFORMANCE CT
ISSN号	0002-7863
DOI	10.1021/jacs.8b04169
文献子类	期刊论文
英文摘要	Iron oxide nanoparticle (IONP)-based magnetic resonance imaging (MRI) contrast agents have been widely used for the diagnosis of hepatic lesions. However, current IONP-based liver-specific MRI contrast agents rely on single-phase contrast enhancement of the normal liver, which is not sensitive enough to detect early stage small hepatocellular carcinomas (HCCs). We herein report i-motif DNA-assisted pH-responsive iron oxide nanocluster assemblies (termed RIAs), which provide an inverse contrast enhancemt effect to improve the distinction between normal liver and target HCC tissues. The acidic pH of the tumor microenvironment triggers the disassembly of the RIAs, which leads to a drastic decrease in their relaxivity ratio (r(2)/r(1)), thus converting the RIAs from a T2 to T1 contrast agent. This inverse contrast enhancement of normal liver darkening and HCC brightening under T1 imaging mode was validated on an orthotopic HCC model. Our design provides a novel strategy for the exploitation of the next-generation intelligent MRI contrast agents.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/30972]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 2.Shanghai Jiao Tong Univ, Inst Mol Med, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China 3.Zhejiang Univ, MOE Key Lab Biomed Engn, Coll Biomed Engn & Instrument Sci, Hangzhou 310058, Zhejiang, Peoples R China 4.Zhejiang Univ, Dept Radiol, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China 5.Inst for Basic Sci Korea, Ctr Nanoparticle Res, Seoul 08826, South Korea 6.Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 08826, South Korea 7.Zhejiang Univ, Zhejiang Prov Key Lab Anticanc Drug Res, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 8.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys,Div Phys Biol, Shanghai 201800, Peoples R China 9.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys,Bioimaging Ctr, Shanghai 201800, Peoples R China
推荐引用方式 GB/T 7714	Lu, JX,Sun, JH,Li, FY,et al. Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2018,140(32):10071-10074.
APA	Lu, JX.,Sun, JH.,Li, FY.,Wang, J.,Liu, JN.,...&Ling, DS.(2018).Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,140(32),10071-10074.
MLA	Lu, JX,et al."Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblies".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140.32(2018):10071-10074.