DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides

doi:10.1002/adhm.201701153

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides
	Hu, QQ ; Wang, S ; Wang, LH ; Gu, HZ ; Fan, CH
刊名	ADVANCED HEALTHCARE MATERIALS
	2018
卷号	7 期号:20 页码:-
关键词	ANTICANCER DRUG-DELIVERY SINGLE-STRANDED-DNA DOUBLE-CROSSOVER MOLECULES IMMUNOSTIMULATORY CPG DNA SPHERICAL NUCLEIC-ACIDS TARGETED CANCER-THERAPY SIRNA DELIVERY GOLD NANOPARTICLES RNA INTERFERENCE GENE-REGULATION
ISSN号	2192-2640
DOI	10.1002/adhm.201701153
文献子类	期刊论文
英文摘要	In the beginning of the 21st century, therapeutic oligonucleotides have shown great potential for the treatment of many life-threatening diseases. However, effective delivery of therapeutic oligonucleotides to the targeted location in vivo remains a major issue. As an emerging field, DNA nanotechnology is applied in many aspects including bioimaging, biosensing, and drug delivery. With sequence programming and optimization, a series of DNA nanostructures can be precisely engineered with defined size, shape, surface chemistry, and function. Simply with hybridization, therapeutic oligonucleotides including unmethylated cytosine-phosphate-guanine dinucleotide oligos, small interfering RNA (siRNA) or antisense RNA, single guide RNA of the regularly interspaced short palindromic repeat-Cas9 system, and aptamers, are successfully loaded on DNA nanostructures for delivery. In this progress report, the development history of DNA nanotechnology is first introduced, and then the mechanisms and means for cellular uptake of DNA nanostructures are discussed. Next, current approaches to deliver therapeutic oligonucleotides with DNA nanovehicles are summarized. In the end, the challenges and opportunities for DNA nanostructure-based systems for the delivery of therapeutic oligonucleotides are discussed.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/30907]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China 2.Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Div Phys Biol, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 4.Chinese Acad Sci, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
推荐引用方式 GB/T 7714	Hu, QQ,Wang, S,Wang, LH,et al. DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(20):-.
APA	Hu, QQ,Wang, S,Wang, LH,Gu, HZ,&Fan, CH.(2018).DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides.ADVANCED HEALTHCARE MATERIALS,7(20),-.
MLA	Hu, QQ,et al."DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides".ADVANCED HEALTHCARE MATERIALS 7.20(2018):-.