Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing

doi:10.1093/nsr/nwx134

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing
	Yang, F ; Zuo, XL ; Fan, CH ; Zhang, XE
刊名	NATIONAL SCIENCE REVIEW
	2018
卷号	5 期号:5 页码:740-755
关键词	SEQUENCE-SPECIFIC DETECTION ULTRASENSITIVE ELECTROCHEMICAL DETECTION E-DNA SENSOR ANTIBODY IMMOBILIZATION ELECTRONIC DETECTION FEMTOMOLAR DNA STRAND DISPLACEMENT MESSENGER-RNA NUCLEIC-ACIDS CANCER-CELLS
ISSN号	2095-5138
DOI	10.1093/nsr/nwx134
文献子类	期刊论文
英文摘要	Biosensors are a type of important biodevice that integrate biological recognition elements, such as enzyme, antibody and DNA, and physical or chemical transducers, which have revolutionized clinical diagnosis especially under the context of point-of-care tests. Since the performance of a biosensor depends largely on the bio-solid interface, design and engineering of the interface play a pivotal role in developing quality biosensors. Along this line, a number of strategies have been developed to improve the homogeneity of the interface or the precision in regulating the interactions between biomolecules and the interface. Especially, intense efforts have been devoted to controlling the surface chemistry, orientation of immobilization, molecular conformation and packing density of surface-confined biomolecular probes (proteins and nucleic acids). By finely tuning these surface properties, through either gene manipulation or self-assembly, one may reduce the heterogeneity of self-assembled monolayers, increase the accessibility of target molecules and decrease the binding energy barrier to realize high sensitivity and specificity. In this review, we summarize recent progress in interfacial engineering of biosensors with particular focus on the use of protein and DNA nanostructures. These biomacromolecular nanostructures with atomistic precision lead to highly regulated interfacial assemblies at the nanoscale. We further describe the potential use of the high-performance biosensors for precision diagnostics.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/30864]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China 2.Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Hubei, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China 4.Chinese Acad Sci, Inst Biophys, CAS Excellence Ctr Biomacromol, Natl Key Lab Biomacromol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Yang, F,Zuo, XL,Fan, CH,et al. Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing[J]. NATIONAL SCIENCE REVIEW,2018,5(5):740-755.
APA	Yang, F,Zuo, XL,Fan, CH,&Zhang, XE.(2018).Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing.NATIONAL SCIENCE REVIEW,5(5),740-755.
MLA	Yang, F,et al."Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing".NATIONAL SCIENCE REVIEW 5.5(2018):740-755.