New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats

CORC > 昆明动物研究所 > 昆明动物研究所 > 管理、支撑部门 > 大型仪器中心

	New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats
	Liu, NX; Wang, Y; Yang, MF; Bian, WX; Zeng, L; Yin, SG; Xiong, ZQ; Hu, Y; Wang, SY; Meng, BL
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2019
卷号	67 期号:1 页码:220-228
ISSN号	0021-8561
英文摘要	Gout that caused by hyperuricemia affects human health seriously and more efficient drugs are urgently required clinically. In this study, a novel peptide named RDP1 (AAAAGAKAR, 785.91 Da) was identified from the extract of shelled fruits of Oryza sativa. Our results demonstrated that RDP1 (the minimum effective concentration is 10 mu g/kg) could significantly reduce the serum uric acid and creatinine and alleviate hyperuricemic nephropathy in rats by intragastric administration. RDP1 inhibited xanthine oxidase, which also was verified at the animal level. Results from molecular docking indicated that RDP1 can inhibit uric acid formation by occupying the binding site of xanthine oxidase to xanthine. Besides, RDP1 showed no toxicity on rats and was stable in several temperatures, demonstrating its advantages for transportation. This research was the first discovery of antihyperuricemic peptide from the shelled fruits of O. Sativa and provided a new candidate for the development of hypouricemic drugs.
语种	英语
内容类型	期刊论文
源URL	[http://ir.kiz.ac.cn:8080/handle/152453/12528]
专题	管理、支撑部门_大型仪器中心
推荐引用方式 GB/T 7714	Liu, NX,Wang, Y,Yang, MF,et al. New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(1):220-228.
APA	Liu, NX.,Wang, Y.,Yang, MF.,Bian, WX.,Zeng, L.,...&Yang, XW.(2019).New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(1),220-228.
MLA	Liu, NX,et al."New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.1(2019):220-228.