Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice. | |
Yanmei Chen1; Jichuan Zhang1; Yingjie An1; Jun Cao2; Jianhong Wang2,3 | |
刊名 | Clinical and Experimental Pharmacology and Physiology |
2018 | |
卷号 | 45期号:4页码:335-343 |
关键词 | Dopamine Memory Mice Morphine |
DOI | 10.1111/1440-1681.12889 |
英文摘要 | Both opiates and dopamine play important roles in learning and memory. Althoughsynergistic action between these two neurotransmitters has been found, their func-tional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopa-mine receptor agonists (apomorphine 0.05 mg/kg; SKF38393 0.01 mg/kg;bromocriptine 0.05 mg/kg), which have no effects on spatial recognition memory,were injected intraperitoneally into mice 30 minutes before a memory test in a two-trial recognition Y- maze. The Y- maze is based on the innate tendency of rodents toexplore novel environments and is therefore suitable for exploring the effects of mor-phine on learning and memory. Our results showed that both D1- like and D2- like do-pamine receptor agonists dose- dependently impaired the retrieval of spatialrecognition memory in the Y- maze, and co- administration of memory ineffectivedoses of apomorphine (0.05 mg/kg), SKF38393 (0.01 mg/kg), or bromocriptine(0.05 mg/kg) and of morphine (2.5 mg/kg) resulted in impaired spatial recognitionmemory retrieval in mice. These findings suggest the existence of interactions be-tween morphine and dopamine receptor agonists in memory processing and that acti-vation of the dopamine system might contribute to morphine- induced impairment ofmemory, which could provide insight into human addiction. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/12231] |
专题 | 灵长类研究中心 |
通讯作者 | Jianhong Wang |
作者单位 | 1.Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China 2.Laboratory of Ecology & Evolutionary Biology, Yunnan University, Kunming, Yunnan, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China |
推荐引用方式 GB/T 7714 | Yanmei Chen,Jichuan Zhang,Yingjie An,et al. Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice.[J]. Clinical and Experimental Pharmacology and Physiology,2018,45(4):335-343. |
APA | Yanmei Chen,Jichuan Zhang,Yingjie An,Jun Cao,&Jianhong Wang.(2018).Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice..Clinical and Experimental Pharmacology and Physiology,45(4),335-343. |
MLA | Yanmei Chen,et al."Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice.".Clinical and Experimental Pharmacology and Physiology 45.4(2018):335-343. |
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