The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物毒素室

	The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis
	Rong, MQ; Liu, J; Liao, Q; Lin, ZL; Wen, B; Ren, Y; Lai, R
刊名	AMINO ACIDS
	2019
卷号	51 期号:2 页码:345-353
ISSN号	0939-4451
英文摘要	The diversity of defensive peptides from skin of amphibians has been demonstrated. These peptides may have resulted from the diversity of microorganisms encountered by amphibians. In this study, peptidomics and RNA sequencing analyses were used to study deeply the defensive peptides of the skin secretions from Polypedates megacephalus. A total of 99 defensive peptides have been identified from the skin secretions. Among these peptides, 3 peptides were myotropical peptides and 34 peptides classified as protease inhibitor peptides. 5 lectins, 8 antimicrobial peptides, 26 immunomodulatory peptides, 10 wound-healing peptides and 13 other bioactive peptides were identified as belonging to the innate immune system. One antimicrobial peptide Pm-amp1 showed high similarity to antimicrobial peptide marcin-18. This peptide was successfully expressed and showed moderate activity against four tested strains. These identified peptides highlight the extensive diversity of defensive peptides and provide powerful tools to understand the defense weapon of frog.
语种	英语
内容类型	期刊论文
源URL	[http://ir.kiz.ac.cn:8080/handle/152453/12448]
专题	昆明动物研究所_动物毒素室
推荐引用方式 GB/T 7714	Rong, MQ,Liu, J,Liao, Q,et al. The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis[J]. AMINO ACIDS,2019,51(2):345-353.
APA	Rong, MQ.,Liu, J.,Liao, Q.,Lin, ZL.,Wen, B.,...&Lai, R.(2019).The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis.AMINO ACIDS,51(2),345-353.
MLA	Rong, MQ,et al."The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis".AMINO ACIDS 51.2(2019):345-353.