Regio- and Enantioselective Palladium-Catalyzed Allylic Alkylation of Nitromethane with Monosubstituted Allyl Substrates: Synthesis of (R)-Rolipram and (R)-Baclofen

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 金属有机化学国家重点实验室

	Regio- and Enantioselective Palladium-Catalyzed Allylic Alkylation of Nitromethane with Monosubstituted Allyl Substrates: Synthesis of (R)-Rolipram and (R)-Baclofen
	Yang XF(杨晓菲) ; Ding CH(丁昌华) ; Li XH(李小惠) ; Huang JQ(黄建强) ; Hou XL(侯雪龙) ; Dai LX(戴立信) ; Wang PJ(王贫杰)
刊名	J. Org. Chem.
	2012
卷号	77 期号:20 页码:8980-8985
ISSN号	0022-3263
其他题名	硝基甲烷与单取代烯丙基底物的钯催化区域和对映选择性烯丙基烷基化反应: (R)-Rolipram 和 (R)-Baclofen的合成
通讯作者	侯雪龙
英文摘要	The Pd-catalyzed asymmetric allylic alkylation (AAA) reaction of nitromethane with monosubstituted allyl substrates was realized for the first time to provide corresponding products in high yields with excellent regio-and enantioselectivities. The protocol was applied to the enantioselective synthesis of (R)-baclofen and (R)-rolipram.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/jo301506p
语种	英语
WOS记录号	WOS:000309951700014
公开日期	2013-08-22
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28145]
专题	上海有机化学研究所_金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Yang XF,Ding CH,Li XH,et al. Regio- and Enantioselective Palladium-Catalyzed Allylic Alkylation of Nitromethane with Monosubstituted Allyl Substrates: Synthesis of (R)-Rolipram and (R)-Baclofen[J]. J. Org. Chem.,2012,77(20):8980-8985.
APA	杨晓菲.,丁昌华.,李小惠.,黄建强.,侯雪龙.,...&王贫杰.(2012).Regio- and Enantioselective Palladium-Catalyzed Allylic Alkylation of Nitromethane with Monosubstituted Allyl Substrates: Synthesis of (R)-Rolipram and (R)-Baclofen.J. Org. Chem.,77(20),8980-8985.
MLA	杨晓菲,et al."Regio- and Enantioselective Palladium-Catalyzed Allylic Alkylation of Nitromethane with Monosubstituted Allyl Substrates: Synthesis of (R)-Rolipram and (R)-Baclofen".J. Org. Chem. 77.20(2012):8980-8985.