Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution

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	Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution
	Yin F(尹锋) ; Wang ZT(王振涛) ; Li ZD(李兆栋) ; Li CZ(李超忠)
刊名	J. Am. Chem. Soc.
	2012
卷号	134 期号:25 页码:10401-10404
ISSN号	0002-7863
其他题名	水溶液中银催化的脂肪酸脱羧氟代
通讯作者	李超忠
英文摘要	Although fluorinated compounds have found widespread applications in the chemical and materials industries, general and site-specific: C(sp(3))-F bond formations are still a challenging task. We report here that with the catalysis of AgNO3, various aliphatic carboxylic acids undergo efficient decarboxylative fluorination with SELECTFLUOR (R) reagent in aqueous solution, leading to the synthesis of the corresponding alkyl fluorides in satisfactory yields under mild conditions. This radical fluorination method is not only efficient and general but also chemoselective and functional-group-compatible, thus making it highly practical in the synthesis of fluorinated molecules. A mechanism involvinig Ag(III)-mediated single electron transfer followed by fluorine atom transfer is proposed for this catalytic fluorodecarboxylation.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ja3048255
语种	英语
WOS记录号	WOS:000305716700024
公开日期	2013-08-22
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/27955]
专题	上海有机化学研究所_金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Yin F,Wang ZT,Li ZD,et al. Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution[J]. J. Am. Chem. Soc.,2012,134(25):10401-10404.
APA	尹锋,王振涛,李兆栋,&李超忠.(2012).Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution.J. Am. Chem. Soc.,134(25),10401-10404.
MLA	尹锋,et al."Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution".J. Am. Chem. Soc. 134.25(2012):10401-10404.