Caerulomycins and Collismycins Share a Common Paradigm for 2,2 '-Bipyridine Biosynthesis via an Unusual Hybrid Polyketide-Peptide Assembly Logic

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	Caerulomycins and Collismycins Share a Common Paradigm for 2,2 '-Bipyridine Biosynthesis via an Unusual Hybrid Polyketide-Peptide Assembly Logic
	Ju XD(瞿旭东) ; Pang B(庞博) ; Zhang ZC(张志聪) ; Chen M(陈明) ; Wu ZH(吴竹华) ; Zhao QF(赵群飞) ; Zhang QL(张庆林) ; Wang YY(王银燕) ; Liu Y(刘运) ; Liu W(刘文)
刊名	J. Am. Chem. Soc.
	2012
卷号	134 期号:22 页码:9038-9041
ISSN号	0002-7863
其他题名	Caerulomycins和Collismycins采用相同的非典型杂合聚酮/非核糖体聚肽合成酶合成2,2'-联二吡啶核心结构
通讯作者	瞿旭东 ; 刘文
英文摘要	Caerulomycins (CAEs) and collismycins (COLs), which mainly differ in sulfur decoration, are two groups of structurally similar natural products containing a 2,2'-bipyridine (2,2'-BP) core, derivatives of which have been widely used in chemistry. The biosynthetic pathways of CAEs and COLs remain elusive. In this work, cloning of the CAE biosynthetic gene cluster allowed us to mine a highly conserved gene cluster encoding COL biosynthesis in a Streptomyces strain that was previously unknown as a 2,2'-BP producer. In vitro and in vivo investigations into the biosynthesis revealed that CAEs and COLs share a common paradigm featuring an atypical hybrid polyketide synthase/nonribosomal peptide synthetase system that programs the 2,2'-BP formation. This likely involves an unusual intramolecular cyclization/rearrangement sequence, and a difference in processing of the sulfhydryl group derived from the same precursor cysteine drives the biosynthetic route toward CAEs or COLs.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ja3016457
语种	英语
WOS记录号	WOS:000304837800005
公开日期	2013-08-23
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28501]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Ju XD,Pang B,Zhang ZC,et al. Caerulomycins and Collismycins Share a Common Paradigm for 2,2 '-Bipyridine Biosynthesis via an Unusual Hybrid Polyketide-Peptide Assembly Logic[J]. J. Am. Chem. Soc.,2012,134(22):9038-9041.
APA	瞿旭东.,庞博.,张志聪.,陈明.,吴竹华.,...&刘文.(2012).Caerulomycins and Collismycins Share a Common Paradigm for 2,2 '-Bipyridine Biosynthesis via an Unusual Hybrid Polyketide-Peptide Assembly Logic.J. Am. Chem. Soc.,134(22),9038-9041.
MLA	瞿旭东,et al."Caerulomycins and Collismycins Share a Common Paradigm for 2,2 '-Bipyridine Biosynthesis via an Unusual Hybrid Polyketide-Peptide Assembly Logic".J. Am. Chem. Soc. 134.22(2012):9038-9041.