Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma

doi:10.3892/or.2019.7181

	Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma
	He, Hui 2; Chen, Di 1; Cui, Shimeng 3; Piao, Hailong 1; Tang, Haibo 2; Wang, Xun 2; Ye, Peng 4; Jin, Shi 2
刊名	ONCOLOGY REPORTS
	2019-08-01
卷号	42 期号:2 页码:745-752
关键词	lncRNA ceRNA network HCC OIP5-AS1 topological analysis
ISSN号	1021-335X
DOI	10.3892/or.2019.7181
通讯作者	Jin, Shi(jinshi_1969@hotmail.com)
英文摘要	The present study was designed to identify the endogenous RNA regulatory networks involved in hepatocellular carcinoma (HCC) by bioinformatic analysis. Both miRNA interaction network-based correlation analysis and expression-based Spearman correlation coefficients were utilized to identify potential mRNA-lncRNA interactions. Then, a competitive endogenous (ce)RNA network was constructed from these interactions, and network topology and Gene Ontology enrichment analyses were conducted to mine potential functions of ceRNAs. In HCC samples, a ceRNA network was constructed. It was composed of 35,657 edges connecting 113 lncRNAs and 6,136 mRNAs which were differentially expressed in HCC and normal liver tissues. Meanwhile, a number of significantly positively correlated mRNA and lncRNA pairs in this ceRNA network were found to be consistently positively correlated in another independent dataset. To be noted, further analyses on the potential roles of ceRNAs demonstrated than various lncRNAs such as LINC00657, TUG1 and SNHG1 may play key roles in HCC by regulating protein phosphorylation or cell cycle pathways or influencing miRNAs. From the perspective that lncRNAs can function as ceRNAs, this study revealed that the interaction between lncRNAs, miRNAs and mRNAs may provide new insight for the diagnosis and treatment in the tumorigenesis of hepatocellular carcinoma.
资助项目	National Natural Science Foundation of China[NSFC 81702526]
WOS关键词	PROGNOSTIC MARKERS ; CERNA ; MICRORNAS ; LNCRNA ; CHEMOPREVENTION ; PROLIFERATION ; EXPRESSION ; SPONGES ; OBESITY ; CANCER
WOS研究方向	Oncology
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000475611600024
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/173954]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Jin, Shi
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Dept Laparoscop Surg, 193 Lianhe Rd, Dalian 116000, Liaoning, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Dalian 116000, Liaoning, Peoples R China 4.Liaoning Canc Hosp & Inst, Dept Urol Surg, Shenyang 110042, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	He, Hui,Chen, Di,Cui, Shimeng,et al. Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma[J]. ONCOLOGY REPORTS,2019,42(2):745-752.
APA	He, Hui.,Chen, Di.,Cui, Shimeng.,Piao, Hailong.,Tang, Haibo.,...&Jin, Shi.(2019).Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma.ONCOLOGY REPORTS,42(2),745-752.
MLA	He, Hui,et al."Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma".ONCOLOGY REPORTS 42.2(2019):745-752.