ESIPT Fluorescence Probe Based on Double-Switch Recognition Mechanism for Selective and Rapid Detection of Hydrogen Sulfide in Living Cells

doi:10.1021/acsomega.9b00934

	ESIPT Fluorescence Probe Based on Double-Switch Recognition Mechanism for Selective and Rapid Detection of Hydrogen Sulfide in Living Cells
	Guan, Hongwei 1; Zhang, Aixia 2; Li, Peng 3; Xia, Lixin 2; Guo, Feng 1
刊名	ACS OMEGA
	2019-05-01
卷号	4 期号:5 页码:9113-9119
ISSN号	2470-1343
DOI	10.1021/acsomega.9b00934
通讯作者	Xia, Lixin(lixinxia@lnu.edu.cn) ; Guo, Feng(0411guofeng@dlut.edu.cn)
英文摘要	A novel fluorescence probe, HBTSeSe, was designed and synthesized for the detection of H2S with a double-switch mechanism of a broken diselenide bond followed by thiolysis of ether. Then, 2-(2'-hydroxyphenyl) benzothiazole (HBT) was released as fluorophore, which has large Stokes shift based on the excited state intramolecular proton transfer process. The probe responded selectively and rapidly to H2S, with the fluorescence increased by 47-fold immediately after the addition of H2S. HBTSeSe was able to detect H2S in the cytoplasm, specifically in cell imaging experiments. The results also showed that H2S was produced in the immune response of RAW264.7 cells activated by phorbol-12-myristate-13-acetate.
资助项目	China National Natural Science Foundation[31270620] ; China National Natural Science Foundation[21673237] ; Dalian Scientific and Technological Innovation Foundation[2018J12SN072]
WOS关键词	PROTON-TRANSFER ; SULFANE SULFUR ; SELENIUM ; H2S ; DISELENIDES ; BODIPY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000470094000134
资助机构	China National Natural Science Foundation ; China National Natural Science Foundation ; Dalian Scientific and Technological Innovation Foundation ; Dalian Scientific and Technological Innovation Foundation ; China National Natural Science Foundation ; China National Natural Science Foundation ; Dalian Scientific and Technological Innovation Foundation ; Dalian Scientific and Technological Innovation Foundation ; China National Natural Science Foundation ; China National Natural Science Foundation ; Dalian Scientific and Technological Innovation Foundation ; Dalian Scientific and Technological Innovation Foundation ; China National Natural Science Foundation ; China National Natural Science Foundation ; Dalian Scientific and Technological Innovation Foundation ; Dalian Scientific and Technological Innovation Foundation
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/172111]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Xia, Lixin; Guo, Feng
作者单位	1.Dalian Univ Technol, Sch Food & Environm, Minist Educ, Key Lab Ind Ecol & Environm Engn, Panjin 124000, Peoples R China 2.Liaoning Univ, Dept Chem, Shenyang 110036, Liaoning, Peoples R China 3.Chinese Acad Sci, DICP, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Guan, Hongwei,Zhang, Aixia,Li, Peng,et al. ESIPT Fluorescence Probe Based on Double-Switch Recognition Mechanism for Selective and Rapid Detection of Hydrogen Sulfide in Living Cells[J]. ACS OMEGA,2019,4(5):9113-9119.
APA	Guan, Hongwei,Zhang, Aixia,Li, Peng,Xia, Lixin,&Guo, Feng.(2019).ESIPT Fluorescence Probe Based on Double-Switch Recognition Mechanism for Selective and Rapid Detection of Hydrogen Sulfide in Living Cells.ACS OMEGA,4(5),9113-9119.
MLA	Guan, Hongwei,et al."ESIPT Fluorescence Probe Based on Double-Switch Recognition Mechanism for Selective and Rapid Detection of Hydrogen Sulfide in Living Cells".ACS OMEGA 4.5(2019):9113-9119.