Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues

doi:10.1021/acs.orglett.9b00935

	Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues
	Wang, Lei 2; Liu, Bin 2; Liu, Yuxue 1; Sun, Yue 2; Liu, Wujun 3; Yu, Dayu 2; Zhao, Zongbao K.1
刊名	ORGANIC LETTERS
	2019-05-03
卷号	21 期号:9 页码:3218-3222
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b00935
通讯作者	Yu, Dayu(yudy@neepu.edu.cn) ; Zhao, Zongbao K.(zhaozb@dicp.ac.cn)
英文摘要	An Escherichia coli strain was constructed for the efficient import of nicotinamide adenine dinucleotide (NAD) analogues into cells by limiting extracellular degradation while expressing an efficient NAD importer. In vivo functions of three NAD analogues were characterized. Nicotinamide hypoxanthine dinucleotide was identified as an inhibitor of NAD synthesis. Nicotinamide cytosine dinucleotide had excellent biocompatibility and was used for characterizing a growth-dependent degradation of in vivo nicotinamide cofactors.
资助项目	National Natural Science Foundation of China[21708003] ; National Natural Science Foundation of China[31470787] ; National Natural Science Foundation of China[21837002] ; Science and Technology Research Project of Jilin Province, China[20170519015JH]
WOS关键词	NAD(+) TRANSPORTER ; COFACTORS ; IDENTIFICATION ; IMPORT
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000467320000052
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/172060]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Yu, Dayu; Zhao, Zongbao K.
作者单位	1.Chinese Acad Sci, Div Biotechnol, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Northeast Elect Power Univ, Sch Chem Engn, Jilin 132012, Peoples R China 3.Dalian Med Univ, Inst Canc Stem Cell, Dalian 116044, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lei,Liu, Bin,Liu, Yuxue,et al. Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues[J]. ORGANIC LETTERS,2019,21(9):3218-3222.
APA	Wang, Lei.,Liu, Bin.,Liu, Yuxue.,Sun, Yue.,Liu, Wujun.,...&Zhao, Zongbao K..(2019).Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues.ORGANIC LETTERS,21(9),3218-3222.
MLA	Wang, Lei,et al."Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues".ORGANIC LETTERS 21.9(2019):3218-3222.