Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures

doi:10.1039/c8sm02504e

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures
	Li L(李龙); Hu JL; Li L; Song F(宋凡)
刊名	SOFT MATTER
	2019-05-07
卷号	15 期号:17 页码:3507-3514
ISSN号	1744-683X
DOI	10.1039/c8sm02504e
通讯作者	Hu, Jinglei(hujinglei@nju.edu.cn) ; Song, Fan(songf@lnm.imech.ac.cn)
英文摘要	Cell adhesion is crucial for immune response, tissue formation, and cell locomotion. The adhesion process is mediated by the specific binding of membrane-anchored receptor and ligand proteins. These adhesion proteins are in contact with the membranes and may generate curvature, which has been shown for a number of membrane proteins to play an important role in membrane remodeling. An important question remains of whether the local membrane curvatures induced by the adhesion proteins affect their binding. We've performed Monte Carlo simulations of a mesoscopic model for membrane adhesion via the specific binding of curvature-inducing receptors and ligands. We find that the curvatures induced by the adhesion proteins do affect their binding equilibrium constant. We presented a theory that takes into account the membrane deformations and protein-protein interactions due to the induced curvatures, and agrees quantitatively with our simulation results. Our study suggests that the ability to induce membrane curvatures represents a molecular property of the adhesion proteins and should be carefully considered in experimental characterization of the binding affinity.
分类号	二类/Q1
资助项目	National Key Research and Development Program of China[2016YFA0501601] ; National Natural Science Foundation of China[21504038] ; National Natural Science Foundation of China[11472285] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
WOS关键词	ATOMIC-FORCE MICROSCOPY ; VIRIAL-COEFFICIENTS ; KINETICS ; ADHESION ; TCR ; MECHANISMS ; INCLUSIONS ; DIFFUSION ; PROTEINS ; SELF
WOS研究方向	Chemistry ; Materials Science ; Physics ; Polymer Science
语种	英语
WOS记录号	WOS:000471298900021
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
其他责任者	Hu, Jinglei ; Song, Fan
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/79376]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Li L,Hu JL,Li L,et al. Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures[J]. SOFT MATTER,2019,15(17):3507-3514.
APA	李龙,Hu JL,Li L,&宋凡.(2019).Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures.SOFT MATTER,15(17),3507-3514.
MLA	李龙,et al."Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures".SOFT MATTER 15.17(2019):3507-3514.